左氧氟沙星治疗口腔颌面部间隙感染致过敏性休克1例  

A case of levofloxacin-induced anaphylactic shock in a patient with oral and maxillofacial space infection

作　　者：郭志刚 房秀梅 杨建森[1] 贾天祺 郑利光[1] GUO Zhigang;FANG Xiumei;YANG Jiansen;JIA Tianqi;ZHENG Liguang(Department of Pharmacy,Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology,Beijing,100081,China;Department of Pharmacy,Dongzhimen Hospital of Beijing University of Chinese Medicine)

机构地区：[1]北京大学口腔医学院·口腔医院药剂科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,100081 [2]北京中医药大学东直门医院药学部

出　　处：《实用口腔医学杂志》2024年第4期584-586,共3页Journal of Practical Stomatology

基　　金：北京市自然科学基金资助项目(编号:9204031);北京大学口腔医(学)院管理科研基金资助(编号:2023GLJJ10)。

摘　　要：口腔颌面部间隙感染(OMSI)多为混合感染,常需要抗需氧菌和抗厌氧菌药物联合治疗。左氧氟沙星等第三代喹诺酮类抗菌药物因肌腱断裂等严重不良反应限制了在OMSI中使用。该研究利用药品不良反应关联性评价方法和文献研究法,针对1例临床药师参与的OMSI患者使用左氧氟沙星后发生过敏性休克的病例进行分析,给出了合理用药和不良反应处理建议,为临床快速辨析不良反应及可疑药物、确定应对方案提供借鉴,完善OMSI用药选择,及时救治了休克,有效地治愈了OMSI。Oral and maxillofacial space infection(OMSI)as a mostly mixed infection,often requires the combination of anti-aerobe and anti-anaerobe antibiotics.The use of third-generation quinolones,such as levofloxacin,is limited in OMSI due to the tendon rupture and other serious adverse drug reactions(ADR).In the treatment of a case with OMSI and anaphilactic shock induced by levofloxacin,the association evaluation method of ADR and literature review method participated by clinical pharmacists were used.Suggestions on rational drug use and ADR treatment were gained,the patient was timely rescued from anaphylactic and cured of OMSI.

关 键 词：左氧氟沙星 过敏性休克 颌面间隙感染 药物不良反应 

分 类 号：R782.3[医药卫生—口腔医学]