肿瘤生长形式与肿瘤出芽对判断胃癌患者预后的价值分析  

Prognostic significance of tumor growth pattern and tumor budding in patients with gastric cancer

作　　者：龚文品 Gong Wen-pin(Gastrointestinal Surgery Unit II of General Surgery,Nanyang Central Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市中心医院普通外科胃肠二病区,河南南阳473000

出　　处：《四川生理科学杂志》2024年第7期1518-1521,1585,共5页

摘　　要：目的:探究肿瘤生长形式(Tumor growth form,TGP)与肿瘤出芽(Tumor budding,TB)对胃癌患者预后的判断价值。方法:选取我院2021年6月至2023年1月收治的82例接受手术根治的胃癌患者,取病理组织进行TGP和TB判断,并根据判定结果将患者分为扩张性组和侵袭性组、低TB组和高TB组。采用Kaplan-Meier生存曲线评价各组的总生存期(Overall survival,OS)和无病生存期(Disease-free survival,DFS)。采用Cox风险模型评价胃癌患者的预后影响因素。结果:82例胃癌患者中,复发/转移4例,死亡22例。TGP为扩张性生长型29例,中间型患者23例,纳入扩张性组,侵袭性生长型30例纳入侵袭性组;TB1患者有37例,TB2患者有30例,将其纳入低TB,TB3患者有15例,纳入高TB组。扩张性组和侵袭性组在分化程度、TNM分期、T分期、N分期、CEA值、OS和DFS间差异有统计学意义(P<0.05)。低TB和高TB组在分化程度、TNM分期、N分期、OS和DFS间差异有统计学意义(P<0.05)。经多因素Cox比例风险分析发现,TGP和TB是胃癌患者术后OS的独立影响因素,TGP是DFS的独立影响因素(P<0.05)。结论:TGP和TB均为胃癌患者的预后的独立影响因素,对胃癌患者预后均有一定的预测价值。Objective:To evaluate the prognostic significance of tumor growth pattern(TGP)and tumor budding(TB)in patients with gastric cancer.Methods:Eighty-two patients who underwent radical surgery for gastric cancer in our hospital from June 2021 to January 2023 were selected,and pathological tissues were collected for the evaluation of TGP and TB,then the patients were classified into expansive/invasive groups and low/high TB groups.Overall survival(OS)and disease-free survival(DFS)were analyzed by the Kaplan-Meier method,and Cox proportional hazards model regression analysis was used to identify prognostic factors of gastric cancer.Results:Of the 82 patients with gastric cancer,4 had recurrence/metastasis and 22 died.In terms of TGP,29 patients classified as expansive growth pattern and 23 patients as intermediate growth pattern were set as expansive group,and 30 patients classified as invasive growth pattern were included in invasive group.In terms of TB,37 cases of low budding(TB1)and 30 cases of intermediate budding(TB2)were set as low TB group,and 15 cases of high budding(TB3)were classified into high TB group.Statistical difference was reported between the expansive group and invasive group in terms of the degree of differentiation,TNM staging,T staging,N staging,carcinoembryonic antigen(CEA)values,OS,and DFS(P<0.05).The low TB group and high TB group demonstrated statistical differences in the degree of differentiation,TNM stage,N stage,OS,and DFS(P<0.05).Multivariate Cox proportional hazards analysis denoted that TGP and TB were independent influencing factors for postoperative OS in gastric cancer patients,while TGP was an independent influencing factor for DFS(P<0.05).Conclusion:Both TGP and TB are independent factors affecting the prognosis of gastric cancer patients,and both are of certain predictive value for the prognosis of gastric cancer patients.

关 键 词：肿瘤生长形式 肿瘤出芽 胃癌 预后 

分 类 号：R735.2[医药卫生—肿瘤]