Periodontitis exacerbates pulmonary hypertension by promoting IFNγ^(+)T cell infiltration in mice  

作　　者：Xiaoqian Meng Linjuan Du Shuo Xu Lujun Zhou Boyan Chen Yulin Li Chumao Chen Huilin Ye Jun Zhang Guocai Tian Xuebing Bai Ting Dong Wenzhen Lin Mengjun Sun Kecong Zhou Yan Liu Wuchang Zhang Shengzhong Duan 

机构地区：[1]Department of Endodontics,Shanghai Ninth People’s Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]Laboratory of Oral Microbiota and Systemic Diseases,Shanghai Ninth People’s Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai,China [3]Hongqiao International Institute of Medicine,Shanghai Tongren Hospital/Faculty of Basic Medicine,Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education,Shanghai Jiao Tong University School of Medicine,Shanghai,China [4]Department of Orthodontics,Shanghai Ninth People’s Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,Shanghai,China [5]Department of Periodontology,Shanghai Ninth People’s Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,Shanghai,China [6]Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Hangzhou,China

出　　处：《International Journal of Oral Science》2024年第2期359-369,共11页国际口腔科学杂志（英文版）

基　　金：fundings from the National Natural Science Foundation of China(82330015,81991503,81921002,and 82303275);Science and Technology Commission of Shanghai Municipality(23ZR1438300).

摘　　要：Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the disease.In the current study,we showed that experimental periodontitis,which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis,exacerbated hypoxia-induced pulmonary hypertension in mice.Mechanistically,periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs,contributing to pulmonary infiltration of interferon gamma positive(IFNγ^(+))T cells and aggravating the progression of pulmonary hypertension.In addition,we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving the exacerbation of pulmonary hypertension by periodontitis,and the exacerbation was potently ameliorated by both cervical lymph node excision and IFNγneutralizing antibodies.Our study suggests a proof of concept that the combined prevention and treatment of periodontitis and pulmonary hypertension are necessary.

关 键 词：HYPERTENSION PREVENTION INTERFERON 

分 类 号：R544.1[医药卫生—心血管疾病] R781.42[医药卫生—内科学]