AMPK缺陷促进神经病理性疼痛的机制及药物研究进展  

Progress in mechanism and drugs for AMPK deficiency-related neuropathic pain

作　　者：胡娇 张莉 张琴 李豪 徐德林 徐陶 HU Jiao;ZHANG Li;ZHANG Qin;LI Hao;XU Delin;XU Tao(Department of Physiology,Zunyi Medical University,Zunyi 563000,China;Department of Pediatric Intensive Care Unit,The Third Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China;Department of Cell Biology,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学生理学教研室,贵州遵义563000 [2]遵义医科大学第三附属医院儿童重症医学科,贵州遵义563000 [3]遵义医科大学细胞生物学教研室,贵州遵义563000

出　　处：《中国病理生理杂志》2024年第7期1307-1315,共9页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.82160160)。

摘　　要：神经病理性疼痛往往由神经系统原发性损害和功能障碍所引起,患者常表现为自发性疼痛或痛觉过敏症状。近年研究表明,AMP活化蛋白激酶(AMP-activated protein kinase,AMPK)作为关键的能量调节因子,不仅通过调节糖脂代谢参与维持机体内环境稳定,也可以通过相关信号通路调节突触可塑性和神经胶质细胞功能,在一些神经系统疾病的发生与进展中发挥作用。近年来,多项针对神经病理性疼痛的动物模型实验和临床研究表明,在感觉传导通路的多个位点上,AMPK的表达及活性异常,给予AMPK激动剂治疗后,疼痛症状缓解,这提示AMPK的表达/功能异常参与了神经病理性疼痛的发生与维持,因此基于AMPK的镇痛药物研发受到广泛关注。本文就AMPK参与神经病理性疼痛相关机制的进展进行综述,希望能够为相关镇痛药物研发提供参考。Neuropathic pain is a chronic pain condition caused by damage or dysfunction of the nervous system.Symptoms of neuropathic pain include spontaneous pain,hyperalgesia,and sensory abnormalities.AMP-activated protein kinase(AMPK)is a key energy regulator that maintains cellular homeostasis by modulating carbohydrate and lipid metabolism.Recent studies have highlighted its role in synaptic plasticity and glial cell function,suggesting that AMPK signaling pathways contribute to the onset and progression of neurological disorders.Investigations using animal models of neuropathic pain as well as clinical research have illustrated aberrations in AMPK expression and activity at various sites along sensory conduction pathways.Treatment with AMPK agonists has been shown to alleviate pain symptoms,suggesting that dysregulation of AMPK expression/function contributes to the development and persistence of neuropathic pain.Therefore,the development of analgesics targeting AMPK has garnered considerable attention worldwide.This article provides a comprehensive review of the mechanisms by which AMPK participates in neuropathic pain,with the aim of guiding the development of related analgesic drugs.

关 键 词：神经病理性疼痛 AMP活化蛋白激酶 镇痛药 

分 类 号：R745[医药卫生—神经病学与精神病学] R441.1[医药卫生—临床医学] R363