肠道菌群对乳腺癌发生发展的影响及其治疗应用的研究进展  

Research progress in effect of intestinal flora on occurrence and development of breast cancer and its therapeutic application

作　　者：付晓敏 贾建玲 窦艳红 任文勇 石爱平[1] FU Xiaomin;JIA Jianling;DOU Yanhong;REN Wenyong;SHI Aiping(Department of Breast Surgery,First Hospital,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院乳腺外科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2024年第4期1182-1188,共7页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅科技发展计划项目(20190701041GH);吉林省教育厅技术研究项目(JJKH20231217KJ)。

摘　　要：乳腺癌发病率逐年上升,其发病机制十分复杂。肠道菌群功能紊乱与乳腺癌发生发展有密切关联。肠道菌群产生的β-葡萄糖醛酸酶,可通过肠肝循环调节雌激素水平,进而影响激素受体阳性乳腺癌的发生发展并导致他莫昔芬耐药;肠道菌群来源的短链脂肪酸(SCFAs)和石胆酸(LCA)等代谢产物可参与调节肿瘤细胞周期和细胞增殖;肠道菌群的定植维持了肠道屏障的完整性并调控T淋巴细胞介导的抗肿瘤免疫。维持肠道菌群稳态可提高肿瘤化疗和免疫治疗效果,并减轻抗肿瘤治疗中的不良反应。免疫治疗中工程益生菌的靶向作用可协助提升药物治疗精准度。肠道菌群对放射治疗的影响尚不明确,但调节肠道菌群可辅助治疗放射性肠病。现对肠道菌群与乳腺癌的相关性及影响进行综述,并分析其在乳腺癌治疗中的作用。The incidence of breast cancer is increasing year by year,and its pathogenesis is highly complex.The dysregulation of gut microbiota function is closely related to the occurrence and development of breast cancer.The estrogen levels through enterohepatic circulation is regulated byβ-glucuronidase produced by the gut microbiota,thereby influencing the occurrence and development of hormone receptor-positive breast cancer and leading to tamoxifen resistance.The metabolites from the gut microbiota,such as short-chain fatty acids(SCFAs)and lithocholic acid(LCA),can participate in regulating the tumor cell cycles and cell proliferation.The colonization of gut microbiota maintains the integrity of the intestinal barrier and regulates the anti-tumor immunity mediated by T lymphocytes.Maintaining gut microbiota homeostasis can enhance the efficacy of tumor chemotherapy and immunotherapy and reduce the adverse reactions in anti-tumor treatments.The targeted action of engineered probiotics in immunotherapy can improve the precision of drug treatment.The effect of gut microbiota on radiotherapy is not yet clear,but regulating gut microbiota can aid in the treatment of radiation enteritis.This review discusses the correlation and effect of gut microbiota on breast cancer and analyzes its role in the treatment of breast cancer.

关 键 词：乳腺肿瘤 肠道菌群 雌激素代谢 免疫调节 

分 类 号：R737.9[医药卫生—肿瘤]