基于脂筏治疗相关疾病的研究进展  

Research progress on the use of lipid rafts microdomains in disease treatment

作　　者：杨蕊红 杨帅虎 马玉雪 方诗剑 肖洪彬[1] 牛雯颖[1] YANG Ruihong;YANG Shuaihu;MA Yuxue;FANG Shijian;XIAO Hongbin;NIU Wenying(Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《海南医学院学报》2024年第15期1187-1193,共7页Journal of Hainan Medical University

基　　金：国家自然科学基金资助项目(82274405,82074326)。

摘　　要：“LR微区域”又称LR(lipid raft,LR)是细胞膜上的一类功能区域,富含糖脂、鞘磷脂以及胆固醇。在机体的免疫和炎症过程中,LR是重要的参与者。癌症、神经系统疾病、传染病和心血管等疾病常伴随LR的失调或缺陷等病理表现。本文基于细胞和及分子层面概述LR的结构及组成,挖掘靶向LR治疗相关疾病的方法和机制并探讨其相关性,对比了基于LR机制的中药和西药发挥药效的差异,以期对相关疾病的研究和临床治疗提供新的思路。lipid rafts microregions,also known as lipid rafts(LR),are a type of functional region on the cell membrane that is rich in sugars,lipids,sphingolipids,and cholesterol.LR is an important participant in the immune and inflammatory processes of the body.Diseases such as cancer,neurological disorders,infectious diseases,and cardiovascular diseases are often accompanied by pathological manifestations such as dysregulation or deficiency of LR.This article provides an overview of the structure and composition of LR at the cellular and molecular levels,explores the methods and mechanisms of targeted LR treatment for related diseases,and explores their correlation.It compares the differences in the efficacy of traditional Chinese medicine and Western medicine based on LR mechanism,in order to provide new ideas for the research and clinical treatment of related diseases.

关 键 词：LR LR疗法 神经系统疾病 肿瘤 感染性疾病 

分 类 号：R363[医药卫生—病理学]