中医药治疗增生性玻璃体视网膜病变研究进展  

Research Progress on the Treatment of Proliferative Vitreoretinopathy with Tradi-tional Chinese Medicine

作　　者：虞玥 赵敏瑶 宋正宇 YU Yue;ZHAO Minyao;SONG Zhengyu(Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海201203

出　　处：《中国中医眼科杂志》2024年第8期786-789,共4页China Journal of Chinese Ophthalmology

基　　金：上海市自然科学基金项目(18ZR1440200);上海中医药大学附属曙光医院“四明青年基金”项目(SGKJ-202111)。

摘　　要：增生性玻璃体视网膜病变(PVR)是导致孔源性视网膜脱离手术失败和复发的主要原因,目前西医治疗以手术为主,但存在不足之处,中医药治疗PVR成为目前的研究热点。本文旨在综述近年来中、西医对PVR的认识,并整理归纳已被证实具有防治效果的中药单体及复方制剂的相关文献,发现PVR与肝、脾、肾等脏腑功能状态密切相关,为中医药在PVR治疗的应用提供了理论基础。同时,藏红花酸、三七总皂苷、青蒿琥酯等中药单体以及活血散结方、散血明目片、大黄蛰虫丸等中药复方制剂能通过多条信号通路,抑制视网膜色素上皮细胞增殖迁移和上皮-间质转化等生物学进程,进而起到防治PVR的作用。这些研究为中医药防治PVR提供科学依据,提示中医药治疗PVR具有潜力和优势。Proliferative vitreoretinopathy(PVR)is a major cause of surgical failure and recur-rence in rhegmatogenous retinal detachment.Currently,Western Medicine primarily relies on sur-gery for treatment,but there are limitations.Traditional Chinese Medicine(TCM)treatment of PVR has become a research hotspot.This article aims to review recent advances in both Western Medicine and TCM understanding of PVR.It summarizes and categorizes relevant literature on the efficacy of single Chinese medicine and compound formulations that have been proven effective in prevention and treatment.It is found that PVR is closely related to the functional status of organs such as liver,spleen,and kidney,providing a theoretical basis for the application of TCM in PVR treatment.Meanwhile,single Chinese medicine such as saffron acid,total saponins of Panax no-toginseng,and artemether,as well as compound formulations such as Huoxue Sanjie Decoction,Sanxue Mingmu Tablet,and Dahuang Zhechong Pill,can inhibit biological processes such as pro-liferation,migration,and epithelial-mesenchymal transition of retinal pigment epithelial cells through multiple signaling pathways,thereby preventing and treating PVR.These studies provide a scientific basis for TCM in preventing and treating PVR,indicating the potential and advantages of TCM in PVR treatment.

关 键 词：中医药 增生性玻璃体视网膜病变 研究进展 

分 类 号：R774.1[医药卫生—眼科] R276.7[医药卫生—临床医学]