前列腺癌脑膜转移2例  

Two cases of meningeal metastasis from prostate cancer

作　　者：贾文学[1] 王吉 朱岳峰 刘彦廷[1] 艾文兵 田春雷[1] JIA Wen-xue;WANG Ji;ZHU Yue-feng;LIU Yan-ting;AI Wen-bing;TIAN Chun-lei(Neurology Institute,Three Gorges University&Department of Neurosurgery,First Clinical College of Three Gorges University(Yichang Central People's Hospital),Yichang 443003;Department of Neurosurgery,Yilin Hospital,Yichang 443003,China)

机构地区：[1]三峡大学神经病学研究所/三峡大学第一临床医学院&宜昌市中心人民医院神经外科,湖北宜昌443003 [2]宜昌市夷陵医院神经外科,湖北443003

出　　处：《中国临床神经外科杂志》2024年第4期248-250,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：前列腺癌是全球第二常见的男性恶性肿瘤。近年来,随着我国人口老龄化的加剧,前列腺癌的发病率越来越高。前列腺癌较易发生远处转移,其中骨转移最为常见,脑转移十分罕见。前列腺癌脑转移多发生在疾病晚期,由于缺乏早期筛查手段,且临床治疗方法有限,预后较差。本文报道2例前列腺癌脑膜转移,其中1例64岁,采用手术全切除肿瘤联合术后放疗、内分泌治疗,术后5个月随访,生活自理;1例70岁,采用手术全切除肿瘤,术后未行辅助放化疗,术后6个月随访,生活自理。因此,在临床工作中,老年男性脑膜病变鉴别诊断时,应考虑到前列腺来源的可能。对于前列腺癌脑膜转移,如果病人全身状况良好、颅外疾病控制较好,可采用手术切除肿瘤联合术后放化疗,有助于延长病人的生存期。Prostate cancer ranks as the second most prevalent malignancy in men globally.The aging population in China has contributed to a notable increase in prostate cancer incidence.Notably,prostate cancer frequently metastasizes distantly,with bone metastasis being predominant and brain metastasis rare.Brain metastases from prostate cancer typically manifest in advanced stages of the disease and are associated with a poor prognosis due to limited early screening modalities and clinical interventions.This paper reports two cases of meningeal metastases originating from prostate cancer.One case involved a 64-year-old patient who underwent surgical resection followed by postoperative radiotherapy and endocrine therapy,achieving independent living at a 5-month follow-up.The other case featured a 70-year-old patient who underwent surgery without adjuvant radiotherapy or chemotherapy,also attaining independent living at a 6-month follow-up.Therefore,when differentiating meningeal space-occupying lesions in elderly men,consideration should be given to the potential of a prostate origin.For patients presenting with meningeal metastases stemming from prostate cancer,if the patient's general condition is good and the extracranial disease is well controlled,surgical resection combined with radiotherapy and chemotherapy can help prolong the patient's survival outcomes.

关 键 词：脑转移瘤 前列腺癌 显微手术 预后 

分 类 号：R739.41[医药卫生—肿瘤] R651.11[医药卫生—临床医学]