中国阿尔茨海默病早期预防指南(2024)  

Chinese Guidelines for Early Prevention of Alzheimer’s Disease(2024)

作　　者：林璐[1] 马辛[2] 王刚[3] 王虹峥[4] 王志群 王志稳[6] 王晓明[7] 王惠芳[8] 朱飞奇 乔立艳[10] 刘肇瑞[11] 齐志刚[12] 汤彬 李坤成[12] 李朝辉 肖世富[15] 郁金泰 周显波 赵禾欣[18] 赵忙所[10] 赵红彬[19] 顾耘[20] 郭红[21] 郭玲[22] 郭起浩[23] 富丽萍 雷敏[25] 潘伟刚[2] 徐勇[26] 王军[27] 阿尔茨海默病防治协会 Lu LIN;Xin MA;Gang WANG;Hongzheng WANG;Zhiqun WANG;Zhiwen WANG;Xiaoming WANG;HuifangWANG;Feiqi ZHU;Liyan QIAO;Zhaorui LIU;Zhigang QI;Bin TANG;Kuncheng LI;Zhaohui LI;Shifu XIAO;Jintai YU;Xianbo ZHOU;Hexin ZHAO;Mangsuo ZHAO;Hongbin ZHAO;Yun GU;Hong GUO;Ling GUO;Qihao GUO;Liping FU;Min LEI;Weigang PAN;Yong XU;Jun WANG;China association for Alzheimer'sdisease(The First Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu,China;Beijing Anding Hospital Capital Medical University,Beijing 100032,China;Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025;Peking Union Medical College,Beijing 100005,China;Aerospace Center Hospital,Beijing 10049,China;School of Nursing,Peking University,Beijing 100191,China;Affiliated Hospital of North Sichuan Medical College,Nanchong 637002,Sichuan,China;Yangzhi Rehabilitation Hospital Affiliated to Tongji University(Shanghai Sunshine Rehabilitation Center),Shanghai 201613,China;Department of Neurology,Shenzhen Luohu Hospital Group Luohu People’s Hospital/The third Affiliated Hospital of Shenzhen University,Shenzhen 518001,Guangdong,China;Tsinghua University Yuquan Hospital,Beijing 100040,China;Peking University Sixth Hospital,Beijing 100083,China;Xuanwu Hospital Capital Medical University,Beijing 10005,China;Shanghai Jian’ai Public Welfare Development Center,Shanghai 201824,China;The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Mental Health Center affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200023,China;Huashan Hospital Affiliated to Fudan University,National Center for Neurology,Shanghai 200040;Alzheimer’s Research Center,Washington Institute for Clinical Research(USA),AstraNeura Pharma Co.,Ltd.,Shanghai 200131,China;Beijing Hospital,Beijing 100730,China;Shanghai Institute of Traditional Chinese Geriatrics,Shanghai 200031,China;Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;School of Nursing,Beijing University of Chinese Medicine,Beijing 102401,C

机构地区：[1]苏州大学附属第一医院,江苏苏州215000 [2]首都医科大学附属北京安定医院,北京100032 [3]上海交通大学医学院附属瑞金医院,上海200025 [4]北京协和医学院,北京100005 [5]航天中心医院影像科,北京100049 [6]北京大学护理学院,北京100191 [7]川北医学院附属医院,四川南充637002 [8]同济大学附属养志康复医院(上海市阳光康复中心),上海201613 [9]深圳市罗湖区人民医院/深圳大学第三附属医院神经内科,广东深圳518005 [10]清华大学玉泉医院,北京100040 [11]北京大学第六医院,北京100083 [12]首都医科大学宣武医院,北京100053 [13]上海剪爱公益发展中心,上海201824 [14]郑州大学第一附属医院,郑州450052 [15]上海交大医学院附属精神卫生中心,上海200025 [16]复旦大学附属华山医院,国家神经疾病医学中心,上海200040 [17]华盛顿临床研究学院阿尔茨海默研究中心(美国),阿斯诺来(上海)医药科技有限公司,上海200131 [18]北京医院,北京100730 [19]上海市中医老年医学研究所,上海200031 [20]上海中医药大学附属龙华医院,上海200032 [21]北京中医药大学护理学院,北京102401 [22]昆明理工大学附属安宁第一人民医院暨昆明市第四人民医院,昆明650302 [23]复旦大学附属华山医院,上海200040 [24]中日友好医院,北京100029 [25]河北医科大学第三医院,河北廊坊065799 [26]苏州大学苏州医学院,江苏苏州215000 [27]北京交通大学,北京100091 [28]阿尔茨海默病防治协会,北京100027

出　　处：《阿尔茨海默病及相关病杂志》2024年第3期168-175,共8页Chinese Journal of Alzheimer's Disease and Related Disorders

摘　　要：阿尔茨海默病是一种病因复杂的严重智力致残疾病,目前尚无有效的治疗方法。我国是世界上老年人口最多、增长最快的国家之一,也是阿尔茨海默病发病率较高的国家。因此,如何早期预防阿尔茨海默病的发生,是现今健康领域最重要的课题之一。我们在国内外相关研究的基础上,通过文献循证、干预研究实践、案例分析、经验总结和专家咨询,结合中国老年健康和社会文化特点,体现中国传统医学、武术、养生以及社区组织优势,制订出具有中国特色的阿尔茨海默病早期预防指南,涵盖了个人、家庭和社会三个层面的预防策略,从积极生活态度、社会活动参与、认知训练、体育锻炼、戒烟限酒、营养、睡眠,血压、血糖、血脂管理,体重和其他慢病管理以及中医开展针对阿尔茨海默病的一级预防。本指南仅供个人、家庭和社会开展阿尔茨海默病预防时参考。Alzheimer's disease(AD)is a severe neurodegenerative disorder with complex etiology,currently lacking effective treatment options.China is among the countries with the largest and fastest-growing elderly population globally,also identified as a high-risk nation for AD.Consequently,early prevention of AD emerges as one of the most crucial endeavors in the fieldof healthcare today.Building upon domestic and international research,we have formulated a Chinese-specific AD early prevention guideline,integrating evidence-based literature,intervention studies,case analyses,experiential insights,and expert consultations,and showcasing the advantages of traditional Chinese medicine,martial arts,health preservation practices,and community organization.This guideline addresses distinctive features of preventive measures and encompasses strategies at the individual,family,and society levels,advocating for proactive lifestyles,social engagement,cognitive training,physical exercise,tobacco cessation and moderate alcohol consumption,nutritional balance,adequate sleep,management of blood pressure,glucose and lipid levels,weight,and other chronic conditions,along with incorporating traditional Chinese medicine(TCM)into primary prevention efforts against AD.This guideline serves as a reference for individuals,families and communities engaged in AD prevention initiatives.

关 键 词：阿尔茨海默病 早期预防 指南 

分 类 号：R74[医药卫生—神经病学与精神病学]