长期服用唑吡坦治疗失眠对认知功能损伤机制的研究进展  

Update on the mechanism of cognitive decline from long-term use of zolpidem in patients with insomnia

作　　者：陈旭辉[1] 贾梦真 胡俊[1] 陈娇 林志坚[1] 张晨 杜芳 孙永安[2] Xuhui CHEN;Mengzhen JIA;Jun HU;Jiao CHEN;Zhijian LIN;Chen ZHANG;Fang DU;Yongan SUN(Department of Neurology,Peking University Shenzhen Hospital,Shenzhen 518000,Guangzhou,China;Department of Neurology,First Hospital,Peking University,Beijing 100034,China;Laboratory of Functional Chemistry and Nutrition of Food,College of Food Science and Engineering,Northwest A&F University,Xianyang 712100,Shaanxi,China;Department of Neurology,Harbin Second Hospital,Harbin 150000,China)

机构地区：[1]北京大学深圳医院神经内科,广东深圳518000 [2]北京大学第一医院神经内科,北京100034 [3]西北农林科技大学食品科学与工程学院,陕西咸阳712100 [4]哈尔滨市第二医院,哈尔滨150000

出　　处：《阿尔茨海默病及相关病杂志》2024年第3期231-235,共5页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：国家自然科学基金(12231018);深圳市科技创新委员会基金(JCYJ2022081802810022)。

摘　　要：非苯二氮䓬类药物(唑吡坦)适用于失眠症的短期治疗,长期大剂量使用可导致严重的不良反应。主要的不良反应包括头晕、头疼、跌倒等,严重的可能出现认知功能下降、行为异常,还有药物的耐受性、依赖性、反跳现象和戒断症状等,导致停药困难。分别从唑吡坦的作用机制、不良反应、耐受性、特殊用药等方面进行综述,阐述唑吡坦对认知功能的损伤机制,旨在为探讨长期使用唑吡坦的慢性睡眠障碍患者如何避免认知功能下降提供借鉴。The non-benzodiazepine sedative-hypnotic drug(Zolpidem)is used for the short-term treatment of insomnia.However,long-term high-dose use may lead to serious adverse reactions such as dizziness,headache,and falls,and may even result in cognitive decline and abnormal behavior.Furthermore,long-term use of Zolpidem may lead to drug tolerance,dependence,rebound phenomena,and withdrawal symptoms,making discontinuation difficult.Therefore,this review aims to provide a review of the mechanism of action,adverse reactions,tolerance,and special use of Zolpidem.To elucidate the mechanism of Zolpidem's adverse effect to cognitive function,in order to help chronic insomnia patients who use zolpidem long-term to avoid cognitive decline.

关 键 词：睡眠障碍 失眠 唑吡坦 认知障碍 

分 类 号：R741[医药卫生—神经病学与精神病学]