Bmi-1在前列腺腺泡腺癌中的表达及意义  

The Expression and Significance of Bmi-1 Protein in Prostate Adenocarcinomas

作　　者：王红群 巩幼洁 朱娅男 华浩铭 WANG Hongqun;GONG Youjie;ZHU Yanan;HUA Haoming(Department of Pathology,the Third People's Hospital of Bengbu City,Bengbu 233000 China;Department of Pathology,the Second People's Hospital of Bengbu City,Bengbu 233000 China)

机构地区：[1]蚌埠市第三人民医院病理科,安徽蚌埠233000 [2]蚌埠市第二人民医院病理科,安徽蚌埠233000

出　　处：《内蒙古医学杂志》2024年第6期661-663,共3页Inner Mongolia Medical Journal

基　　金：安徽省临床医学研究转化专项项目(编号:202204295107020051)。

摘　　要：目的探讨Bmi-1在前列腺腺泡腺癌中的表达及意义。方法使用免疫组化方法,分析Bmi-1在前列腺腺泡腺癌和良性前列腺增生症中的表达情况,比较其与临床病理指标的意义,并和雄激素受体(AR)进行相关性分析。结果Bmi-1在前列腺腺泡腺癌中的阳性率为82.8%(48/58),高于其在前列腺增生症组中的阳性率42.9%(6/14)(P=0.006)。前列腺腺泡腺癌中Bmi-1的表达与AR的表达呈正相关(r=0.331,P=0.011)。结论Bmi-1可能与前列腺腺泡腺癌的发生有关,与AR相互调节发挥作用。Objective To investigate the expression of Bmi-1 protein in prostate adenocarcinomasand its clinicopathologic significance.Methods Bmi-1 protein expression was assessed by immunohistochemistry in 58 cases of prostate adenocarcinomas and 14 cases of beneign prostatic hyperplasia(BPH).The correlations between expression of Bmi-1 protein and clinicopathologic parameters or AR were also analyzed in prostate adenocarcinomas.Results The positive rates of Bmi-1 were 82.8%(48/58)in prostate adenocarcinomas,which were significantly higher than ones in BPHs 42.9%(6/14)(P=0.006).The expression of Bmi-1 in prostate adenocarcinomas was positively correlated with the expression of AR(r=0.331,P=0.011).Conclusion Bmi-1 might be involved in the formation of prostate adenocarcinomas,which may interact with AR and play a role.

关 键 词：前列腺腺泡腺癌 BMI-1 雄激素受体 

分 类 号：R737.25[医药卫生—肿瘤]