脱细胞基质水凝胶治疗周围神经损伤的研究进展  

Research progress of decellularized extracellular matrix hydrogel for peripheral nerve injury

作　　者：刘业祖 刘如恩[1] LIU Yezu;LIU Ru'en(Department of Neurosurgery,Peking University People's Hospital,Beijing 100044,P.R.China)

机构地区：[1]北京大学人民医院神经外科,北京100044

出　　处：《华西医学》2024年第7期1145-1150,共6页West China Medical Journal

摘　　要：周围神经损伤(peripheral nerve injury,PNI)是一种常见的神经功能障碍。临床中通过自体神经移植解决PNI相关供体资源有限、神经瘤形成和供体发病率高等问题。因此,寻找新的神经再生材料成为研究的热点。脱细胞基质(decellularized extracellular matrix,dECM)水凝胶通过去除生物组织中的细胞成分,保留细胞外基质,为神经再生提供支架,是一种有潜力的神经再生治疗材料。该文综述了dECM水凝胶在PNI治疗方面的研究进展,并展望了该研究方向的临床前景。Peripheral nerve injury(PNI)is a common neurological dysfunction.In clinical practice,autologous nerve transplantation is used to solve problems related to PNI,such as limited donor resources,neuroma formation and high donor incidence rate.Therefore,searching for new nerve regeneration materials has become a hot research topic.The decellularized extracellular matrix(dECM)hydrogel provides a scaffold for nerve regeneration by removing the cellular components in biological tissues,preserving the extracellular matrix,and is a potential therapeutic material for nerve regeneration.This article reviews the research progress of dECM hydrogel for PNI and looks forward to the clinical prospects of this research direction.

关 键 词：周围神经损伤 神经修复 脱细胞基质 细胞外基质水凝胶 

分 类 号：R745[医药卫生—神经病学与精神病学]