论帕金森病伴抑郁和原发性抑郁的异质性  

Heterogeneity between Parkinson's disease-associated depression and primary depression

作　　者：张薇 袁灿兴[1] ZHANG Wei;YUAN Canxing(Department of Neurology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院脑病科,上海200032

出　　处：《上海中医药杂志》2024年第8期23-26,40,共5页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市科委科技计划项目(21Y31920300)。

摘　　要：抑郁是帕金森病常见的非运动症状,其虽与原发性抑郁具有相似的临床症状,但二者发病机制及治疗不尽相同。原发性抑郁可归属于中医学“郁证”范畴,帕金森病伴抑郁则属于“颤证”及“郁证”合病。从临床症状、发病机制、西药治疗、中医病因病机、中药治疗等方面论述帕金森病伴抑郁和原发性抑郁的异质性,以期为帕金森病伴抑郁的临床诊疗提供参考。Depression is a common non-motor symptom of Parkinson's disease(PD)and shares similar clinical manifestations with primary depression.However,the pathogenesis and treatment approaches for the two conditions differ.Primary depression can be categorized under the traditional Chinese medicine syndrome of"Yu Zheng"(depression syndrome),while PD-associated depression is considered a comorbidity of"Chan Zheng"(tremor syndrome)and"Yu Zheng".The heterogeneity between PD-associated depression and primary depression is discussed in terms of clinical symptoms,pathogenesis,Western pharmacological treatments,etiology and mechanisms of traditional Chinese medicine,and traditional Chinese medicine treatment.The aim is to provide a reference for the clinical diagnosis and treatment of PD-associated depression.

关 键 词：帕金森病 抑郁 中医药疗法 同病异治 中西医结合疗法 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]