急性粘连性肠梗阻以生长抑素、丙氨酰谷氨酰胺联合进行治疗的效果与安全性  

Efficacy and safety of somatostatin and alanyl glutamine in the treatment of acute adhesive intestinal obstruction

作　　者：邹彬 Zou Bin(Changsha Central Hospital Affiliated to Nanhua University,Changsha,Hunan 410004,China)

机构地区：[1]南华大学附属长沙中心医院,湖南长沙410004

出　　处：《首都食品与医药》2024年第14期70-72,共3页Capital Food Medicine

摘　　要：目的分析急性粘连性肠梗阻以生长抑素、丙氨酰谷氨酰胺联合进行治疗的效果与安全性。方法以南华大学附属长沙中心医院2020年1月-12月内收治的80例急性粘连性肠梗阻患者为此次研究对象,并以治疗方案分为常规组(40例,常规内科治疗)和观察组(40例,常规内科+生长抑素+丙氨酰谷氨酰胺联合治疗),对比分析两组患者的临床症状缓解时间、转手术率、不良反应发生率及未采取手术患者治疗前后的血生化指标、白细胞计数、肛肠压力水平。结果①组间对比,观察组患者腹痛/腹胀持续时间、肛门排气时间、禁饮食时长及转手术率均显著低于常规组(P<0.05),而用药期间的不良反应发生率无显著差异(P>0.05);②观察组患者用药治疗后PCT、CRP、白细胞计数及直肠最大静息压均显著低于常规组(P<0.05),肛管最大静息压、肛管最大收缩压均显著高于常规组(P<0.05)。结论急性粘连性肠梗阻以生长抑素、丙氨酰谷氨酰胺联合治疗,安全性好且疗效显著。Objective To analyze the efficacy and safety of somatostatin combined with alanyl glutamine in the treatment of acute adhesive intestinal obstruction.Method Eighty patients with acute adhesive ilobstruction admitted to our hospital from January to December 2020 were selected as the objects of this study,and were divided into conventional group(40 cases,conventional medical treatment)and observation group(40 cases,conventional medical treatment+somatostatin+alanyl glutamine combined treatment)according to the treatment plan.The duration of clinical symptom relief,the rate of operation transfer,the incidence of adverse reactions,and the blood biochemical indexes,white blood cell count and anorectal pressure before and after the treatment of patients without operation were compared between the two groups.Results①Compared between groups,the duration of abdominal pain/distension,anal exhaust time,abstinence time and operation transfer rate in observation group were significantly lower than those in conventional group(P<0.05),while the incidence of adverse reactions during medication had no significant difference(P>0.05).②After treatment,PCT,CRP,white blood cell count and maximum rectal resting pressure in observation group were significantly lower than those in conventional group(P<0.05),and maximum anal canal resting pressure and maximum anal canal systolic pressure were significantly higher than those in conventional group(P<0.05).Conclusion The combined treatment of somatostatin and alanyl glutamine for acute adhesive intestinal obstruction is safe and effective.

关 键 词：急性粘连性肠梗阻 生长抑素 丙氨酰谷氨酰胺 

分 类 号：R574.2[医药卫生—消化系统]