磁共振技术评估血脑屏障破坏在血管性认知障碍中的应用研究进展  

Assessment of blood-brain barrier dysfunction in vascular cognitive impairment:advances in magnetic resonance imaging technology research

作　　者：王为森 孙旭 李丙翰 毕晓莹 彭雯佳 Wang Weisen;Sun Xu;Li Binghan;Bi Xiaoying;Peng Wenjia(Department of Neurology,the First Affiliated Hospital of Naval Medical University,Shanghai 200433,China;Department of Radiology,the First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院神经内科,上海200433 [2]海军军医大学第一附属医院放射诊断科,上海200433

出　　处：《中华神经科杂志》2024年第7期795-799,共5页Chinese Journal of Neurology

基　　金：上海市科委医学创新研究专项(22Y11911200);上海市自然科学基金(22ZR1478100);国家自然科学基金面上项目(82371495)。

摘　　要：血管性认知障碍是指由血管性因素引起的以认知障碍为特征的一组疾病。血脑屏障的破坏是血管性认知障碍的早期病理生理机制。动态对比增强磁共振技术和基于动脉自旋标记的血脑屏障成像技术能够对血脑屏障的完整性进行量化评估,近年来逐渐被应用于检测血脑屏障破坏程度。文中就相关磁共振技术的基本原理及其在评估血管性认知障碍血脑屏障中的应用进展进行综述。Vascular cognitive impairment is a group of disorders characterized by cognitive dysfunction caused by vascular factors.Disruption of the blood-brain barrier is an early pathophysiological mechanism of vascular cognitive impairment.Dynamic contrast-enhanced magnetic resonance imaging and arterial spin labeling-based blood-brain barrier imaging techniques can quantitatively assess the integrity of the blood-brain barrier.In recent years,these techniques have gradually been applied to detect the extent of blood-brain barrier dysfunction.This article provides a comprehensive review of the basic principles of relevant magnetic resonance techniques and the progress made in their application to the assessment of the blood-brain barrier in vascular cognitive impairment.

关 键 词：认知障碍 血脑屏障 磁共振成像 

分 类 号：R749.13[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]