慢性胃炎幽门螺杆菌感染危险因素及其胃黏膜组织TFF2、HSP70、TGF-βRⅡ表达  

Risk factors for Helicobacter pylori infection in patients with chronic gastritis and expressions of TFF2,HSP70 and TGF-βRⅡin gastric mucosa tissues

作　　者：方松林 冯亮华 陈贇 FANG Song-lin;FENG Liang-hua;CHEN Yun(Xiamen Fifth Hospital,Xiamen,Fujian 361101,China)

机构地区：[1]厦门市第五医院消化内科,福建厦门361101 [2]厦门市第五医院风湿免疫科,福建厦门361101 [3]厦门市第五医院检验科,福建厦门361101

出　　处：《中华医院感染学杂志》2024年第14期2134-2138,共5页Chinese Journal of Nosocomiology

基　　金：福建省自然科学基金资助项目(LH2022H135);厦门市自然科学基金资助项目(3502Z20227420)。

摘　　要：目的 探究慢性胃炎幽门螺杆菌(Hp)感染危险因素及其胃黏膜组织三叶因子2(TFF2)、热休克蛋白70(HSP70)、转化生长因子β受体Ⅱ(TGF-βRⅡ)表达.方法 选取厦门市第五医院2021年2月-2023年2月收治的180例慢性胃炎Hp感染患者为研究组,随机选取180例慢性胃炎未合并Hp感染患者为对照组.通过Lo-gistic 回归法分析慢性胃炎Hp感染危险因素,比较两组胃黏膜组织TFF2、HSP70、TGF-βRⅡ水平;比较研究组TFF2、HSP70、TGF-βRⅡ在不同临床病理特征中的表达,采用受试者工作特征(ROC)曲线分析TFF2、HSP70及TGF-βRⅡ对慢性胃炎Hp感染的诊断价值.结果 饮食方式为共餐、工作压力高、有饮酒史、胃蛋白酶原(PG)-Ⅱ水平低是慢性胃炎Hp感染的危险因素(P<0.05);研究组胃黏膜组织HSP70、TGF-βRⅡ阳性表达占比高于对照组,TFF2阳性表达占比低于对照组(P<0.05);研究组TFF2、HSP70、TGF-βRⅡ阳性表达与发病部位、胃炎/胃癌家族史、饮食习惯是否规律有关(P<0.05);TFF2、HSP70、TGF-βRⅡ联合诊断Hp感染慢性胃炎患者曲线下面积(AUC)高于各指标单一检测(P<0.05),且联合检测敏感度为84.44%,特异度为88.33%.结论 慢性胃炎Hp感染与饮食方式、工作压力、饮酒史、PG-Ⅱ水平相关,其胃黏膜组织TFF2、HSP70及TGF-βRⅡ表达异常,且三者表达与患者发病部位、胃炎/胃癌家族史、饮食习惯有关,三者联合检测可提高其诊断价值.OBJECTIVE To explore the risk factors for Helicobacter pylori(Hp)infection in the patients with chronic gastritis and analyze the expressions of trefoil factor 2(TFF2),heat shock protein 70(HSP70)and trans-forming growth factor-βreceptorⅡ(TGF-βRⅡ)in gastric mucosa tissues.METHODS Totally 180 chronic gastri-tis patients with Hp infection who were treated in Xiamen Fifth Hospital from Feb 2021 to Feb 2023 were assigned as the study group,and 180 chronic gastritis patients who were not complicated with Hp infection were chosen as the control group.Logistic regression analysis was performed for the risk factors for the Hp infection in the chron-ic gastritis patients.The levels of TFF2,HSP70 and TGF-βRⅡin gastric mucosa tissues were compared between the two groups.The expressions of TFF2,HSP70 and TGF-βRⅡwere compared among the patients with differ-ent clinicopathologic characteristics in the study group.The values of TFF2,HSP70 and TGF-βRⅡin diagnosis of Hp infection of the chronic gastritis patients were analyzed by means of receiver operating characteristic(ROC)curves.RESULTS Sharing meals,high working pressure,drinking history and low level of pepsinogen(PG)-Ⅱwere the risk factors for the Hp infection in the chronic gastritis patients(P<0.05).The positive expression levels of HSP70 and TGF-βRⅡin gastric mucosa tissues were significantly higher in the study group than in the control group,while the positive expression level of TFF2 of the study group was significantly lower than that of the con-trol group(P<0.05).The positive expressions of TFF2,HSP70 and TGF-βRⅡin tissues of the study group were associated with the lesion site,family history of gastritis/gastric cancer and dietary habit(P<0.05).The ar-ea under curve(AUC)of the joint detection of TFF2,HSP70 and TGF-βRⅡwas significantly higher than that of the single detection(P<0.05),and the sensitivity of the joint detection was 84.44%,with the specificity 88.33%.CONCLUSION The Hp infection of the chronic gastritis patients is associated

关 键 词：慢性胃炎 幽门螺杆菌 三叶因子2 热休克蛋白70 转化生长因子β受体Ⅱ 受试者工作特征曲线 诊断价值 

分 类 号：R573.3[医药卫生—消化系统]