甲状腺癌EB病毒感染与XRCC1、STING1、IL-10基因多态性及病理类型的关联  

Association between EB virus infection and XRCC1,STING1,IL-10 gene polymorphisms,and types of pathological of patients with thyroid cancer

作　　者：邵辉 李杰[1] 马树民 张静[1] SHAO Hui;LI Jie;MA Shu-min;ZHANG Jing(Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital),Qingdao,Shandong 266000,China)

机构地区：[1]青岛大学附属青岛市海慈医院(青岛市中医医院)甲乳外科,山东青岛266000

出　　处：《中华医院感染学杂志》2024年第14期2158-2162,共5页Chinese Journal of Nosocomiology

基　　金：山东省中医药科技基金资助项目(2020Q30)。

摘　　要：目的 研究甲状腺癌EB病毒感染与X射线交错互补修复基因1(XRCC1)、干扰素基因刺激蛋白1(STING1)、白细胞介素-10(IL-10)基因多态性及病理类型的关联.方法 选取2021年3月-2023年3月青岛大学附属青岛市海慈医院(青岛市中医医院)收治的甲状腺癌患者130例为恶性组,同期收治的138例甲状腺腺瘤患者为良性组,比较两组及不同病理类型甲状腺癌患者EB病毒感染率、XRCC1、STING1、IL-10基因多态性,比较不同EB病毒感染状态甲状腺癌患者XRCC1、STING1、IL-10基因多态性.结果 恶性组EB病毒感染率、XRCC1基因型AA、GA及XRCC1、IL-10等位基因A占比高于良性组,XRCC1基因型GG占比低于良性组(P<0.05);乳头状癌组、滤泡状癌组EB病毒感染率高于髓样癌组、未分化癌组(P<0.05);乳头状癌组、未分化癌组XRCC1等位基因G高于滤泡状癌组、髓样癌组(P<0.05).感染组STING1等位基因C高于非感染组(P<0.05);感染组IL-10基因型CC占比高于非感染组,基因型CA占比低于非感染组(P<0.05).结论 甲状腺癌和甲状腺腺瘤患者EB病毒感染率、XRCC1基因多态性分布具有明显差异,且EB病毒感染可能与甲状腺癌患者病理类型有关,同时IL-10基因多态性可能与甲状腺癌患者EB病毒易感性有关.OBJECTIVE To observe the association between the Epstein-Barr(EB)virus infection and the X-ray cross complementary repair gene 1(XRCC1),stimulator of interferon gene 1(STING1)and interleukin-10(IL-10)gene polymorphisms and types of pathological of the patients with thyroid cancer.METHODS Totally 130 pa-tients with thyroid cancer who were treated in Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)from Mar 2021 to Mar 2023 were assigned as the malignant group,mean-while,138 patients with thyroid adenoma were chosen as the benign group.The incidence of EB virus infection and XRCC1,STING1 and IL-10 gene polymorphisms were compared between the two groups and among the patients with different types of pathological;the XRCC1,STING1 and IL-10 gene polymorphisms were compared among the thyroid cancer patients with different states of EB virus infection.RESULTS The incidence of EB virus infection and the proportions of patients with genotype AA and GA of XRCC1,allele A of XRCC1 and IL-10 were higher in the malignant group than in the benign group,while the proportion of patients with genotype GG of XRCC1 of the malignant group was lower than that of the benign group(P<0.05).The incidence of EB virus infection was high-er in the papillary carcinoma group and the follicular carcinoma group than in the medullary carcinoma group and the undifferentiated carcinoma group(P<0.05).The frequency of allele G of XRCC1 was higher in the papillary carcinoma group and the undifferentiated group than in the follicular carcinoma group and the medullary carcinoma group(P<0.05).The frequency of allele C of STING1 of the infection group was higher than that of the non-in-fection group(P<0.05).The percentage of genotype CC of IL-10 of the infection group was higher than that of the non-infection group,and the percentage of genotype CA of the infection group was lower than that of the non-infection group(P<0.05).CONCLUSION There are significant differences in the incidence of EB virus infec

关 键 词：甲状腺癌 EPSTEIN-BARR病毒 X射线交错互补修复基因1 干扰素基因刺激蛋白1 白细胞介素-10 基因多态性 病理类型 

分 类 号：R736.1[医药卫生—肿瘤]