α,β-不饱和酮分子内Oxa-Michael反应合成黄酮的研究进展  

Research Progress in Synthesis of Flavonoids by Intramolecular Oxa-Michael Reaction ofα,β-Unsaturated Ketones

作　　者：陈致州 CHEN Zhizhou(Minjiang Teachers College,Fuzhou Fujian 350018,China)

机构地区：[1]闽江师范高等专科学校,福建福州350018

出　　处：《辽宁化工》2024年第7期1045-1050,共6页Liaoning Chemical Industry

基　　金：福建省中青年教师教育科研项目资助(项目编号:JAT220666);2023年福州市科协重点调研课题“培育壮大生物医药产业,提升我市药品研制水平”。

摘　　要：黄酮化合物在临床治疗、保健养生等领域具有举足轻重的地位,是一类受到业界追捧的明星分子。Oxa-Michael加成反应广泛应用于构建C-O键反应中,在分子内反应中能够有效构建成环。从以上2个角度出发,归纳总结2-羟基查尔酮底物和2-羟基炔基酮底物通过分子内Oxa-Michael反应构建黄酮骨架化合物的研究进展,对比分析各催化方式的优缺点以及对未来合成方法做进一步展望。Flavonoids play a pivotal role in clinical treatment,health care and other fields,and are a class of star molecules sought after by the industry.Oxa-Michael addition reaction is widely used in the construction of C—O bonds,and it can effectively build rings in intramolecular reactions.From the above two perspectives,the research progress of constructing flavonoid skeleton compounds from 2-hydroxy chalcone substrate and 2-hydroxy alkynyl ketone substrate by intramolecular Oxa-Michael reaction was summarized.The advantages and disadvantages of each catalytic method were compared and analyzed,and the future synthesis methods were prospected.

关 键 词：Oxa-Michael反应 查尔酮 黄酮 抗癌活性 

分 类 号：O623.52[理学—有机化学]