小儿化脓性脑膜炎应用美罗培南治疗的临床价值研究  

Study on the Clinical Value of Application of Meropenem Therapy in Pediatric Purulent Meningitis in Children

作　　者：李艳 杨自金 侍苏杰[1] LI Yan;YANG Zijin;SHI Sujie(Department of Pediatrics,Lianyungang Maternal and Child Health Hospital,Lianyungang 222000,Jiangsu,China)

机构地区：[1]江苏省连云港市妇幼保健院儿科,江苏连云港222000

出　　处：《中外医疗》2024年第17期88-91,共4页China & Foreign Medical Treatment

摘　　要：目的 探究美罗培南应用于小儿化脓性脑膜炎治疗中的效果。方法 方便选取2018年1月—2024年2月江苏省连云港市妇幼保健院收治的62例小儿化脓性脑膜炎患儿为研究对象,依据用药的不同分为两组,每组31例。对照组采用头孢曲松+阿莫西林舒巴坦治疗,观察组在对照组的基础上联合注射用美罗培南治疗。对比两组的康复情况、炎症反应、治疗有效率及不良反应发生情况。结果 观察组体温恢复时间、颅内压降低时间、脑膜刺激征消失时间、脑髓液恢复正常时间均短于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组的炎症因子低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为96.77%,高于对照组的74.19%,差异有统计学意义(χ^(2)=4.679,P=0.031)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 加用美罗培南治疗小儿化脓性脑膜炎可以提高临床治疗疗效,对加快康复速度、降低炎症水平均有重要意义,还可保证患儿用药的安全性。Objective To explore the effect of meropenem application in the treatment of purulent meningitis in children.Methods 62 cases of pediatric purulent meningitis children admitted to Lianyungang Maternal and Child Health Hospital from January 2018 to February 2024 were conveniently selected as the study object,and they were divided into two groups based on the different medications used,with 31 cases in each group.The control group was treated with ceftriaxone + amoxicillin sulbactam,and the observation group was treated with injectable meropenem on the basis of the control group,comparing the recovery,inflammatory response,therapeutic efficiency and the occurrence of adverse reactions in the two groups.Results In the observation group,the recovery time of body temperature,the reduction time of intracranial pressure,the disappearance time of meningeal irritation signs,and the return time of medullary fluid to normal in the observation group were shorter than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the inflammatory factor of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 96.77%,which was higher than 74.19% in the control group,and the difference was statistically significant(χ^(2)=4.679,P=0.031).Comparing the incidence of adverse reactions between the two groups,the difference was not statistically significant(P>0.05).Conclusion The addition of meropenem for the treatment of pediatric purulent meningitis can improve the clinical therapeutic efficacy,which is important for accelerating the speed of recovery and reducing the level of inflammation,and also ensures the safety of children medication.

关 键 词：小儿化脓性脑膜炎 美罗培南 治疗效果 用药安全 

分 类 号：R742[医药卫生—神经病学与精神病学]