免疫组织化学检测在乳腺癌病理诊断中的意义  

The Significance of Immunohistochemical Detection in the Pathological Diagnosis of Breast Cancer

作　　者：贾雅卫 JIA Yawei(Department of Pathology,Xuchang Hospital,Xuchang Henan 461000,China)

机构地区：[1]许昌医院病理科,河南许昌461000

出　　处：《临床研究》2024年第8期135-138,共4页Clinical Research

摘　　要：目的探讨免疫组织化学检测在乳腺癌病理诊断中的意义。方法选取许昌医院2021年1月至2023年1月收治的80例乳腺癌患者作为观察组,另选取同期80例乳腺良性肿瘤患者作为对照组,乳腺癌组织与良性肿瘤组织采用免疫组织化学检测雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER-2)阳性表达,并分析乳腺癌患者临床病理特征与ER、PR、HER-2表达阳性率的相关性。结果观察组ER、PR、HER-2表达阳性率(76.25%、75.00%、72.50%)明显高于对照组(30.00%、26.25%、31.25%),差异均有统计学意义(P<0.05);乳腺癌组织中,不同临床分期、肌层浸润、淋巴结转移、组织学分化的ER、PR、HER-2表达阳性率对比差异均有统计学意义(P<0.05);乳腺癌患者的临床分期、肌层浸润、淋巴结转移、组织学分化与ER、PR、HER-2表达阳性率均存在正相关,差异均有统计学意义(P<0.05)。结论乳腺癌患者多伴有ER、PR、HER-2表达阳性,其与患者临床病理特征有关,通过免疫组织化学检测可为病理诊断提供依据。Objective To explore the significance of immunohistochemical detection in the pathological diagnosis of breast cancer.Methods 80 cases of breast cancer patients treated in Xuchang Hospital from January 2021 to January 2023 were selected as the observation group,and another 80 cases of benign breast tumor patients in the same period were selected as the control group.The breast cancer tissues and benign tumor tissues were subjected to immunohistochemical detection of estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER-2)positive expression,and the correlation between the clinical pathological characteristics of breast cancer patients and the positive expression rate of ER,PR,and HER-2 was analyzed.Results The positive expression rates of ER,PR,and HER-2 in the observation group(76.25%,75.00%,72.50%)were significantly higher than those in the control group(30.00%,26.25%,31.25%),with statistically significant differences(P<0.05).In breast cancer tissues,the positive expression rates of ER,PR,and HER-2 in different clinical stages,muscle layer infiltration,lymph node metastasis,and histological differentiation were compared,and the differences were statistically significant(P<0.05).The clinical stage,muscle layer infiltration,lymph node metastasis,and histological differentiation of breast cancer patients were positively correlated with the positive expression rate of ER,PR,and HER-2,with statistically significant differences(P<0.05).Conclusion Breast cancer patients often have positive expression of ER,PR,and HER-2,which is related to the clinical pathological characteristics of the patients.Immunohistochemical detection can provide a basis for pathological diagnosis.

关 键 词：乳腺癌 免疫组织化学检测 病理诊断 人表皮生长因子受体2 相关性 

分 类 号：R737.9[医药卫生—肿瘤]