ICP-QQQ-MS法分析婴幼儿谷物辅助食品中镉含量的干扰及其校正  

Interferences and Their Elimination in the Determination of Cadmium in Infant Complementary Foods by Inductively Coupled Plasma Triple Quadrupole Mass Spectrometry

作　　者：蔡玮 赵博[1] 赵少雷 陈欢欢 李潇[1] 逯海[1] 韦超[1] CAI Wei;ZHAO Bo;ZHAO Shaolei;CHEN Huanhuan;LI Xiao;LU Hai;WEI Chao(Division of Chemical Metrology and Analytical Science,National Institute of Metrology,Beijing 100029,China;Beijing Institute of Metrology,Beijing 100029,China)

机构地区：[1]中国计量科学研究院化学计量与分析科学研究所,北京100029 [2]北京市计量检测科学研究院,北京100029

出　　处：《食品科学》2024年第14期234-239,共6页Food Science

基　　金：“十三五”国家重点研发计划重点专项(2019YFC1604803)。

摘　　要：建立三重串联四极杆电感耦合等离子体质谱(inductively coupled plasma triple quadrupole mass spectrometry,ICP-QQQ-MS)法测定婴幼儿谷物辅助食品中镉(Cd)含量的方法。研究单四极杆氦气碰撞模式(SQ-He)、串联四极杆氦气碰撞模式(QQQ-He)、串联四极杆氧气反应模式(QQQ-O_(2))3种碰撞/反应模式下质谱测量中存在的各类干扰,并进行逐一分析、消除。结果显示,抗基体、抗氧化物和多原子离子干扰能力均为QQQ-O_(2)>QQQ-He>SQ-He,采用QQQ-O_(2)模式联合标准加入法可获得更为准确的干扰消除效果。通过引入干扰校正方程,有效解决由于同量异位素锡(Sn)干扰导致的Cd同位素丰度比与天然丰度比不一致问题。QQQ-O_(2)模式下同位素稀释质谱法与标准加入法测量Cd的结果等效一致,证明婴幼儿谷物辅助食品中Cd测量时受到的基体效应和质谱干扰被有效消除。所建方法为使用ICP-QQQ-MS准确测定复杂基体样品中Cd提供重要参考。An inductively coupled plasma triple quadrupole mass spectrometric(ICP-QQQ-MS) method was established for the determination of cadmium(Cd) in cereal-based complementary foods for infants and young children.In different collision/reaction modes,namely single quadrupole-helium collision(SQ-He),double quadrupole-helium collision(QQQHe) and double quadrupole-oxygen reaction(QQQ-O_(2)),various possible interferences in the MS measurement process were analyzed and several methods to eliminate them were proposed.The results showed that the decreasing order of the ability to resist matrix,oxide and multiatomic ion interferences was QQQ-O_(2) > QQQ-He > SQ-He.QQQ-O_(2) combined with the standard addition method showed a better ability to eliminate interference.By introducing interference correction equations,the problem of inconsistency between Cd isotope abundance ratio and natural abundance ratio caused by interference from stannum(Sn) isotopes was effectively solved.The results of Cd determination by isotope dilution mass spectrometry(IDMS)in the QQQ-O_(2) mode were consistent with those obtained using the standard addition method,indicating effective elimination of both matrix effect and MS interference.The proposed ICP-QQQ-MS method allows the accuracy determination of Cd in complex matrix samples.

关 键 词：镉 三重串联四极杆电感耦合等离子体质谱 质谱干扰 同位素稀释质谱 基体效应 

分 类 号：O657.63[理学—分析化学]