肺转移性透明细胞肾细胞癌的临床病理学观察  

Clinicopathological observation on clear cell renal cell carcinoma metastasizing to the lung

作　　者：张均林 崔峰 韩思露 王鑫怡 林晓婷 梅开勇[3] ZHANG Junlin;CUI Feng;HAN Silu;WANG Xinyi;LIN Xiaoting;MEI Kaiyong(Department of Pathology,Luoding People′s Hospital,Guangdong 527200,China;Department of Pathology,Huantai TCM Hospital,Zibo 256400,China;Department of Pathology,the Second Affiliated Hospital of Guangzhou Medical University,Guangdong 510260,China)

机构地区：[1]罗定市人民医院病理科,广东527200 [2]桓台县中医院病理科,淄博256400 [3]广州医科大学附属第二医院病理科,广东510260

出　　处：《中国临床新医学》2024年第7期749-752,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广州市科技计划项目(编号:201904010029)。

摘　　要：目的探讨肺转移性透明细胞肾细胞癌临床病理学特点。方法回顾性分析4例穿刺活检诊断肺转移性透明细胞肾细胞癌的临床病理特征,采用免疫组化染色检测CK、p40、p63、TTF-1、Napsin A、PAX8、CD10,观察其表达情况。结果4例患者中,男3例,女1例,年龄44~71岁,平均58.75岁;均为双肺多发结节,其中各例最大的结节位于左下肺2例,右下肺2例。4例均表达CK、PAX8、CD10,而TTF-1、Napsin A、p40、p63阴性。结论具有透明细胞形态特点的肺肿瘤需要考虑肺转移性透明细胞肾细胞癌的可能。Objective To explore the clinicopathological features of clear cell renal cell carcinoma metastasizing to the lung.Methods The clinicopathological features of 4 cases of clear cell renal cell carcinoma metastasizing to the lung which was diagnosed by puncture biopsy were retrospectively analyzed.CK,p40,p63,TTF-1,Napsin A,PAX8 and CD10 were detected by using immunohistochemical staining method,and their expressions were observed.Results Among the 4 patients with clear cell renal cell carcinoma metastasizing to the lung,there were 3 males and 1 female,aged 44-71 years,with an average age of 58.75 years.All the 4 cases had multiple nodules in both lungs,with the largest nodule of each case located in the left lower lobe of the lung in 2 cases and the right lower lobe of the lung in 2 cases.All the 4 cases were positive for CK,PAX8,and CD10 expressions,while negative for TTF-1,Napsin A,p40 and p63 expressions.Conclusion Lung tumors characterized by clear cell morphology need to be considered for the possibility of clear cell renal cell carcinoma metastasizing to the lung.

关 键 词：肺 肾细胞癌 透明细胞 转移 病理 

分 类 号：R730.2[医药卫生—肿瘤]