丁苯酞联合长春西汀注射液对老年高血压合并急性脑梗死患者的神经炎症反应及认知功能的影响  

Effects of Butylphthalein Combined with Vinpocetine Injection on Neuroinflammatory Response and Cognitive Function in Elderly Hypertension Patients Complicated with Acute Cerebral Infarction

作　　者：张晶晶 杨超 田珊珊 ZHANG Jingjing;YANG Chao;TIAN Shanshan(Emergency Department of Taikang Tongji(Wuhan)Hospital,Wuhan 430050,China)

机构地区：[1]泰康同济(武汉)医院急诊科,湖北武汉430050

出　　处：《药物生物技术》2024年第3期260-265,共6页Pharmaceutical Biotechnology

基　　金：湖北省医学科技攻关项目(No.2022070944)。

摘　　要：探讨丁苯酞联合长春西汀注射液对老年高血压合并急性脑梗死患者的神经炎症反应及认知功能的影响。回顾性分析2021年3月至2023年4月医院收治的72例老年高血压合并急性脑梗死患者一般资料,常规治疗结合长春西汀治疗者纳入对照组(n=37),常规治疗结合长春西汀、丁苯酞治疗者纳入观察组(n=35),分析不同治疗方式对患者神经炎症反应、认知功能、生活能力、血管内皮指标、血液流变学指标、氧化应激指标、脑血流动力学指标的影响。治疗后两组左上肢肌力、左下肢肌力、右上肢肌力、右下肢肌力均显著升高,且观察组治疗后以上指标明显高于对照组(P<0.05);治疗后两组精神状态(MMSE)评分、Barthel指数(BI)、认知功能(MoCA)评分均显著升高,神经功能损伤(NIHSS)评分降低,且观察组治疗后MESS评分、BI指数、MoCA评分明显高于对照组,NIHSS评分低于对照组(P<0.05);治疗后两组一氧化氮(NO)水平均显著升高,内皮素(ET)、组织型纤溶酶原激活物抑制物(PAI)、血栓素B2(TXB2)水平降低,且观察组治疗后NO水平高于对照组,ET、PAI、TXB2水平低于对照组(P<0.05);治疗后两组血管内皮生长因子(VEGF)水平降低,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平升高,且观察组治疗后SOD、GSH-Px水平高于对照组,VEGF水平低于对照组(P<0.05);治疗后两组全血高切黏度(HSV)、血浆黏度(PSV)、血浆纤维蛋白原(FIB)水平均显著降低,且观察组治疗后以上指标明显低于对照组(P<0.05);治疗后两组动脉收缩期阻力指数(RI)、搏动指数(PI)水平降低,平均血流速度(Vm)水平升高,且观察组治疗后Vm水平高于对照组,RI、PI水平低于对照组(P<0.05)。丁苯酞联合长春西汀注射液在老年高血压合并急性脑梗死患者中应用较佳,可显著改善神经炎症反应、血管内皮指标、血液流变学指标、氧化应激指标及脑血流动力学状态,提高患�To investigate the effects of butylphthalein combined with vinpocetine injection on neuroinflammatory response and cognitive function in elderly hypertension patients complicated with acute cerebral infarction,general data of 72 elderly hypertension patients with acute cerebral infarction admitted to Taikang Tongji Hospital from March 2021 to April 2023 were retrospectively analyzed.Those treated with conventional treatment combined with vinpocetine were included in the control group(n=37),and those treated with conventional treatment combined with vinpocetine and buphenphthalein were included in the observation group(n=35).The effects of different treatment methods on neuroinflammatory response,cognitive function,life ability,vascular endothelial index,hemorheology index,oxidative stress index and cerebral hemodynamic index were analyzed.The muscle strength of left upper limb,left lower limb,right upper limb and right lower limb were significantly increased in both groups after treatment,and the above indexes in observation group were significantly higher than those in control group after treatment(P<0.05).After treatment,the scores of mental state(MMSE),Barthel index(BI)and cognitive function(MoCA)were significantly increased in both groups,while the scores of neurological impairment(NIHSS)were decreased.After treatment,the score of MESS,BI index and MoCA in the observation group were significantly higher than those in the control group,the NIHSS score was lower than that of control group(P<0.05).After treatment,the levels of nitric oxide(NO)were significantly increased,and the levels of endothelin(ET),tissue plasminogen activator inhibitor(PAI)and thromboxane B2(TXB2)were decreased in both groups.After treatment,the levels of NO in observation group were higher than those in control group,and the levels of ET,PAI and TXB2 were lower than those in control group(P<0.05).After treatment,the levels of vascular endothelial growth factor(VEGF)were decreased,the levels of superoxide dismutase(SOD)and glutathione pero

关 键 词：丁苯酞注射液 长春西汀注射液 老年 高血压合并急性脑梗死 神经炎症反应 认知功能 脑血流动力学 

分 类 号：R743[医药卫生—神经病学与精神病学]