髓源性生长因子的分子机制研究进展  

Advances in Molecular Mechanisms of Myeloid-Derived Growth Factor

作　　者：陈乐彤 何鑫蕊 王航[1] 尹鸿萍[1] CHEN Yuetong;HE Xinrui;WANG Hang;YIN Hongping(School of Life Science and Technology,China Pharmaceutical University,Nanjing 211100,China)

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京211100

出　　处：《药物生物技术》2024年第3期319-324,共6页Pharmaceutical Biotechnology

基　　金：中央高校基本科研业务费专项基金(No.2632022PY04)。

摘　　要：髓源性生长因子是一种由骨髓来源的单核细胞和巨噬细胞分泌产生的蛋白质,具有独特的结构特征,不属于任何已知的细胞因子或生长因子家族,并且与其他蛋白质序列同源性很低。髓源性生长因子在进化上高度保守,在内质网、高尔基体以及细胞外均有存在。研究表明,髓源性生长因子可通过细胞增殖、细胞分化、细胞凋亡以及炎症等相关信号通路,在心血管疾病和代谢疾病中起到一定的作用。探究髓源性生长因子在这些疾病中的分子机制,有助于了解其潜在的治疗用途。文章通过研究和分析现有的文献资料,从髓源性生长因子的蛋白特点及其在不同疾病模型中信号通路进展等方面进行了综述,主要介绍了髓源性生长因子的结构、重组表达、信号通路以及应用方面的研究现状,为后续髓源性生长因子的分子机制研究及应用提供依据。Myeloid-derived growth factor is a protein secreted by bone marrow-derived monocytes and macrophages.It has unique structural characteristics,does not belong to any known family of cytokines or growth factors,and has very low homology with other protein sequences.It is evolutionarily highly conserved and exists in the endoplasmic reticulum,the Golgi apparatus,and extracellular.In the current research,myeloid-derived growth factor may play a role in cardiovascular and metabolic diseases through cell proliferation,cell differentiation,cell apoptosis,and inflammation-related signaling pathways.Exploring the molecular mechanisms of myeloid-derived growth factor in these diseases will help to understand its potential therapeutic use.This review reviewed the protein characteristics of myeloid-derived growth factor and its development in signaling pathways in different disease models.The structure recombination expression,signaling pathway and application of myeloid-derived growth factor were reviewed in this paper,which provided the basis for further research and application of the molecular mechanism of myeloid-derived growth factor.

关 键 词：髓源性生长因子 分子机制 信号通路 细胞增殖 细胞凋亡 细胞分化 炎症 

分 类 号：R363[医药卫生—病理学]