6种平衡型复方氨基酸注射液合成人体蛋白质营养价值的研究  

Study on the nutritional value of human protein synthesized from six balanced compound amino acid injections

作　　者：邸海灵[1] 方灵芝[2] 李尧[3] 于泽芳 吴玉佩 史英钦[2] DI Hai-ling;FANG Ling-zhi;LI Yao;YU Ze-fang;WU Yu-pei;SHI Ying-qin(Department of Clinical Nutrition,The Third Hospital of Hebei Medical University,Shijiazhuang 050051,Hebei China;Department of Pharmacy/Hebei Key Laboratory of Clinical Pharmacy,Hebei General Hospital,Shijiazhuang 050051,Hebei China;Department of Nutrition,Hebei General Hospital,Shijiazhuang 050051,Hebei,China)

机构地区：[1]河北医科大学第三医院临床营养科,河北石家庄050051 [2]河北省人民医院药学部/河北省临床药学重点实验室,河北石家庄050051 [3]河北省人民医院营养科,河北石家庄050051

出　　处：《肠外与肠内营养》2024年第3期143-146,153,共5页Parenteral & Enteral Nutrition

摘　　要：目的:通过对临床常用的6个品种平衡型复方氨基酸注射液(BCAA)18AA(250 mL:12.5 g)、18AA-I(250 mL:17.5 g)、18AA-II(250 mL:21.25 g)、18AA-IV(250 mL:8.7 g)、18AA-V(250 mL:8.06 g)、18AA-V-SF(250 mL:8.06 g)营养价值的研究,为医院药品遴选和临床合理选药提供参考。方法:依据全鸡蛋蛋白模式,对6个品种BCAA必需氨基酸(EAA)第一限制氨基酸化学评分(CS)值、总EAA综合质量(包括必需氨基酸指数、与标准蛋白的贴近度)2个方面评价其营养价值。结果:第一限制氨基酸CS值由高到低为:18AA-II>18AA>18AA-V=18AAV-SF>18AA-I=18AA-IV。总EAA综合质量:必需氨基酸指数由高到低为:18AA-II>18AA>18AA-I>18AA-IV>18AA-V=18AA-V-SF。与全鸡蛋蛋白的贴近度由高到低为:18AA-II=18AA=18AA-I>18AA-IV>18AA-V=18AA-VSF;最终,6个品种BCAA的营养价值由高到低:18AA-II>18AA>18AA-I>18AA-IV>18AA-V=18AA-V-SF。结论:6个品种BCAA中,18AA-II营养价值最高、相同液体量氨基酸含量最高,是肝肾功能正常病人的首选药物。Objective:To provide reference for hospital drug selection and clinical rational drug selection,through evaluating the nutritional value of six commonly used balanced compound amino acid injection(BCAA)in clinical practice,including 18AA(250 mL:12.5 g),18AA-I(250 mL:17.5 g),18AA-II(250 mL:21.25 g),18AA-IV(250 mL:8.7 g),18AA-V(250 mL:8.06 g),and 18AA-V-SF(250 mL:8.06 g).Methods:Based on the whole egg protein model,the nutritional value of six varieties of BCAA from two aspects were evaluated,including the first limiting amino acid chemical score(CS),value of essential amino acid(EAA)and the comprehensive quality of total EAA(both essential amino acid index and closeness to standard protein).Results:The first limiting amino acid CS value from high to low was 18AA-II>18AA>18AA-V=18AA-V-SF>18AA-I=18AA-IV.Total EAA comprehensive quality:the essential amino acid index from high to low was 18AA-II>18AA>18AA-I>18AA-IV>18AA-V=18AA-V-SF.The closeness to whole egg protein from high to low was 18AA-II=18AA=18AA-I>18AA-IV>18AA-V=18AA-V-SF.Ultimately,the nutritional value of the 6 varieties of BCAA decreased from high to low:18AA-II>18AA>18AA-I>18AA-IV>18AA-V=18AA-V-SF.Conclusions:Among the six varieties of BCAA,18AA-II has the highest nutritional value and the highest amino acid content in the same liquid volume,making it the preferred drug for patients with normal liver and kidney function.

关 键 词：平衡型复方氨基酸注射液 全鸡蛋蛋白模式 营养价值 

分 类 号：R459.3[医药卫生—治疗学] R917[医药卫生—临床医学]