安康欣胶囊辅助小切口胃癌根治术治疗胃癌患者的疗效研究  

Efficacy Study of Ankangxin Capsules-Assisted Small Incision Radical Gastrectomy for Gastric Cancer Patients

作　　者：李翰嵩 姚远[1] 张磊[1] 赵辉[1] 韩龙才[1] 李景武[1] LI Han-song;YAO Yuan;ZHANG Lei;ZHAO Hui;HAN Long-cai;LI Jing-wu(Second Department of Gastrointestinal Surgery,Tangshan People′s Hospital,Tangshan Hebei 063001)

机构地区：[1]河北省唐山市人民医院胃肠外二科,河北唐山063001

出　　处：《世界中西医结合杂志》2024年第7期1354-1360,1365,共8页World Journal of Integrated Traditional and Western Medicine

基　　金：2022年度河北省医学科学研究课题计划(20220217)。

摘　　要：目的观察安康欣胶囊辅助小切口胃癌根治术治疗胃癌(Gastric carinoma,GC)的临床疗效。方法选取2021年8月-2022年8月期间河北省唐山市人民医院收治的70例胃癌患者,按随机数字表法分为对照组和观察组,每组各35例。对照组予以小切口胃癌根治术,术后进行营养干预,观察组在对照组基础上加用安康欣胶囊。两组疗程均为4周。观察比较两组患者治疗前后中医证候积分(纳食呆滞、胃脘部隐痛、恶心反酸、腹部肿块、大便稀溏)、营养指标[前白蛋白(Prealbumin,PA)、血红蛋白(Hemoglobin,Hb)、总蛋白(Total protein,TP)、白蛋白(Albumin,Alb)、转铁蛋白(Transferrin,TRF)]、胃肠功能指标(肠鸣音恢复时间、首次排气时间、饮食恢复时间、首次排便时间)、肿瘤标志物[癌胚抗原(Carcinoembryonic antigen,CEA)、糖类抗原-724(Carbohydrate antigen-724,CA-724)、糖类抗原-199(Carbohydrate antigen-199,CA-199)、恶性肿瘤生长因子(Malignant tumor growth factor,TSGF)]、复发转移指标[基质金属蛋白酶-2(Matrix metalloproteinase-2,MMP-2)、基质金属蛋白酶-9(Matrix metalloproteinase-9,MMP-9)、血管内皮生长因子(Vascular endothelial growth factor-A,VAGF-A)及VAGF-C]、免疫功能[T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))]的变化情况,随访记录生存期及复发转移率。结果治疗后两组患者中医主症纳食呆滞、胃脘部隐痛、恶心反酸、腹部肿块、大便稀溏证候积分均较治疗前明显降低,差异有统计学意义(P<0.05);且观察组纳食呆滞、胃脘部隐痛、恶心反酸、腹部肿块、大便稀溏证候积分均明显低于对照组,差异有统计学意义(P<0.01)。治疗后观察组肠鸣音恢复时间、首次排气时间、饮食恢复时间和首次排便时间均明显优于对照组,差异有统计学意义(P<0.01)。治疗后两组患者血清PAB、Hb、TP、Alb和TRF指标均较治疗前升高,差异有统计学意义(P<0.05);且观察组血清PABObjective To observe the clinical efficacy of Ankangxin capsules-assisted small incision radical gastrectomy for gastric cancer(GC).Methods From August 2021 to August 2022,70 patients with gastric cancer admitted to Tangshan People′s Hospital in Hebei Province were selected as the study subjects.They were divided into a control and an observation group using the random number table method,with 35 patients in each group.The control group received small incision radical gastrectomy followed by nutritional intervention,while the observation group received Ankangxin capsules based on the control group.Both groups were treated for 4 weeks.Changes in traditional Chinese medicine(TCM)symptom scores[sluggish eating,dull pain in epigastrium,nausea and acid reflux,abdominal masses,loose stools],nutritional indicators[prealbumin(PA),hemoglobin(Hb),total protein(TP),albumin(Alb),transferrin(TRF)],gastrointestinal function indicators[bowel sound recovery time,first flatus time,dietary recovery time,first defecation time],tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen-724(CA-724),carbohydrate antigen-199(CA-199),malignant tumor growth factor(TSGF)],recurrence and metastasis indicators[matrix metalloproteinase-2(MMP-2),matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor-A(VAGF-A)and(VAGF-C)],and immune function[T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))]were observed and compared before and after treatment between the two groups.Survival period,recurrence,and metastasis rate were recorded during follow-up.Results After treatment,TCM main syndrome scores of sluggish eating,dull pain in epigastric,nausea and acid reflux,abdominal masses,and loose stools in both groups were significantly lower than before treatment,with a statistically significant difference(P<0.05).The TCM syndrome scores of the observation group were significantly lower than those of the control group,with a statistically significant difference(P<0.01).The observation group showed significantly better outco

关 键 词：安康欣胶囊 胃癌 小切口胃癌根治术 肿瘤标志物 免疫功能 

分 类 号：R735.2[医药卫生—肿瘤]