参苓胃消胶囊对大肠癌术后化疗患者肿瘤标志物水平及血清Th1/Th2平衡的影响  

Effects of Shenling Weixiao Capsules on Tumor Marker Levels and Serum Th1/Th2 Balance in Postoperative Chemotherapy Patients with Colorectal Cancer

作　　者：王振强[1] 王飞 许迪[1] 徐湘江[1] 赵怡然 WANG Zhen-qiang;WANG Fei;XU Di;XU Xiang-jiang;ZHAO Yi-ran(Internal Medicine of Traditional Chinese Medicine,Cangzhou Hospital of Integrated TCM-WM·Hebei,Cangzhou Hebei 061000)

机构地区：[1]沧州中西医结合医院中医内科,河北沧州061000

出　　处：《世界中西医结合杂志》2024年第7期1415-1420,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局科研计划项目(2020463)。

摘　　要：目的探讨参苓胃消胶囊对大肠癌术后化疗患者肿瘤标志物水平及血清Th1/Th2平衡的影响。方法选取2018年1月-2019年10月期间沧州中西医结合医院收治的86例大肠癌术后化疗患者作为研究对象,依照随机数字表法分为对照组和研究组,每组各43例。对照组采用奥沙利铂联合卡培他滨治疗,研究组在对照组基础上给予参苓胃消胶囊治疗。治疗4个疗程后,观察比较两组患者临床疗效、不良反应、无进展生存时间,治疗前后中医症状评分,KPS评分,血液指标[癌胚抗原(Carcinoembryonicantigen,CEA)、糖类抗原199(Carbohydrateantigen199,CA199),肿瘤坏死因子-α(Tumornecrosisfactor-α,TNF-α)、白细胞介素-4(Interleukin-4,IL-4)、γ-干扰素(Interferon-γ,IFN-γ)、白细胞介素-2(Interleukin-2,IL-2)]。结果治疗后研究组总有效率76.74%(33/43)明显高于对照组55.81%(24/43),差异有统计学意义(P<0.05)。治疗后两组患者纳呆、乏力、腹胀、大便溏烂、口淡不渴、腹痛、脘闷、肠鸣、面色萎黄、浮肿及总分评分均较治疗前降低,差异有统计学意义(P<0.05);且研究组纳呆、乏力、腹胀、大便溏烂、口淡不渴、腹痛、脘闷、肠鸣、面色萎黄、浮肿及总分评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者KPS评分均较治疗前升高,差异有统计学意义(P<0.05);且研究组KPS评分明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清CEA、CA199、TNF-α、IL-4水平均较治疗前降低,IFN-γ、IL-2水平均较治疗前升高,差异有统计学意义(P<0.05),且研究组TNF-α、IL-4水平均明显低于对照组,IFN-γ、IL-2水平均明显高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者胃肠道反应、骨髓抑制、神经系统损伤、血液学毒性发生率比较,差异无统计学意义(P>0.05)。随访至2022年2月28日,随访4个月~36个月,两组患者中位无进展生存曲线比较,差异Objective To explore the effect of Shenling Weixiao capsules on tumor marker levels and serum Th1/Th2 balance in postoperative chemotherapy patients with colorectal cancer.Methods A total of 86 postoperative chemotherapy patients with colorectal cancer,admitted to Cangzhou Hospital of Integrated TCM-WM·Hebei between January 2018 to October 2019,were selected as the study subjects.They were divided into a control and a study group according to the random number table method,with 43 patients in each group.The control group was treated with oxaliplatin combined with capecitabine,while the study group was treated with Shenling Weixiao capsule based on the control group.After 4 treatment courses,the clinical efficacy,adverse reactions,progression-free survival time,Traditional Chinese Medicine(TCM)symptom scores,KPS scores,blood markers[carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),Tumor necrosis factor-α(TNF-α),Interleukin-4(IL-4),Interferon-γ(IFN-γ),Interleukin-2(IL-2)],were observed and compared between the two groups.Results After treatment,the overall effective rate in the study group(76.74%,33/43)was significantly higher than in the control group(55.81%,24/43),with a statistically significant difference(P<0.05).Symptom scores for anorexia,fatigue,abdominal distension,loose stools,tasteless mouth,abdominal pain,epigastric oppression,bowel sounds,sallow complexion,edema,and total score significantly decreased in both groups compared to before treatment.Moreover,anorexia,fatigue,abdominal distension,loose stools,tasteless mouth,abdominal pain,epigastric oppression,bowel sounds,sallow complexion,edema,and total score in the study group were significantly lower than those of the control group,with a statistically significant difference(P<0.05).KPS scores significantly increased in both groups compared to before treatment,and the KPS score of the study group was significantly higher than that of the control group,with a statistically significant difference(P<0.05).Serum levels of CEA,CA199,TNF-α,

关 键 词：参苓胃消胶囊 大肠癌 肿瘤标志物 

分 类 号：R735.3[医药卫生—肿瘤]