美沙拉秦联合盐酸小檗碱片治疗溃疡性结肠炎患者的临床效果  

Clinical Effect of Mesalazine Combined with Berberine Hydrochloride Tablets in the Treatment of Patients with Ulcerative Colitis

作　　者：张秀云 计泽宇 姜郝 ZHANG Xiuyun;JI Zeyu;JIANG Hao(Yancheng First People's Hospital,Yancheng 224000,China;不详)

机构地区：[1]盐城市第一人民医院,江苏盐城224000

出　　处：《中外医学研究》2024年第19期21-24,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究美沙拉秦联合盐酸小檗碱片治疗溃疡性结肠炎(ulcerative colitis,UC)患者的临床效果。方法:选取2021年3月—2023年3月盐城市第一人民医院收治的100例UC患者作为研究对象。根据随机数表法将其分为对照组和观察组,各50例。两组入院后均采取对症治疗,对照组给予美沙拉秦,观察组在对照组基础上给予盐酸小檗碱片。比较两组临床疗效,症状改善时间,治疗前及治疗3个月后肠道黏膜屏障功能、炎症因子。结果:观察组治疗总有效率为98.00%,显著高于对照组的82.00%,差异有统计学意义(P<0.05)。观察组腹痛、腹泻、脓血便改善时间均早于对照组,差异有统计学意义(P<0.05)。治疗3个月后,两组二胺氧化酶(diamine oxidase,DAO)和D-乳酸(D-lactic acid,D-LA)水平均下降,观察组DAO和D-LA水平均低于对照组,差异有统计学意义(P<0.05)。治疗3个月后,两组C反应蛋白(C-reactive protein,CRP)、白细胞介素-1β(interleukin-1β,IL-1β)水平均显著降低,白细胞介素-10(interleukin-10,IL-10)水平明显升高,观察组CRP、IL-1β水平均低于对照组,IL-10水平明显高于对照组,差异有统计学意义(P<0.05)。结论:美沙拉秦联合盐酸小檗碱片治疗UC效果显著,有效改善肠道黏膜屏障功能,降低炎症因子水平。Objective:To investigate the clinical effect of Mesalazine combined with Berberine Hydrochloride Tablets in the treatment of patients with ulcerative colitis(UC).Method:A total of 100 patients with UC admitted to Yancheng First People's Hospital from March 2021 to March 2023 were selected as the study objects.They were divided into control group and observation group according to random number table method,with 50 cases in each group.Both groups were given symptomatic treatment after admission,the control group was given Mesalazine,and the observation group was given Berberine Hydrochloride Tablets on the basis of the control group.The clinical efficacy,symptom improvement time,intestinal mucosal barrier function and inflammatory factors before and after 3 months of treatment were compared between the two groups.Result:The total effective rate of observation group was 98.00%,which was significantly higher than 82.00%of control group,and the difference was statistically significant(P<0.05).The improvement time of abdominal pain,diarrhea,pus and blood stool in the observation group was earlier than those in the control group,and the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of diamine oxidase(DAO)and D-lactic acid(D-LA)in both groups were decreased,and the levels of DAO and D-LA in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of C-reactive protein(CRP)and interleukin-1β(IL-1β)were significantly decreased in both groups,while the levels of interleukin-10(IL-10)were significantly increased,the levels of CRP and IL-1βin the observation group were lower than those in the control group,and the levels of IL-10 were significantly higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Mesalazine combined with Berberine Hydrochloride Tablets in the treatment of UC can effectively improve intestinal mucosal barrie

关 键 词：溃疡性结肠炎 美沙拉秦 盐酸小檗碱片 肠道黏膜屏障功能 炎症因子 

分 类 号：R574.62[医药卫生—消化系统]