盐酸氟西汀胶囊和草酸艾司西酞普兰片治疗首发抑郁症的临床效果研究  

Clinical efficacy study of fluoxetine hydrochloride capsules and escitalopram oxalate tablets in the treatment of first-episode depression disorder

作　　者：马增明 陈进东 夏玉平 魏晓倩 朱传安 黄志源 MA Zengming;CHEN Jindong;XIA Yuping;WEI Xiaoqian;ZHU Chuan’an;HUANG Zhiyuan(Xiamen Xianyue Hospital,Xiamen Medical College Affiliated Xianyue Hospital,Fujian Psychiatric Center,Fujian Clinical Research Center for Mental Disorders Inpatient Department,Xiamen 361012,Fujian,China;Xiamen Xianyue Hospital,Xiamen Medical College Affiliated Xianyue Hospital,Fujian Psychiatric Center,Fujian Clinical Research Center for Mental Disorders Office,Xiamen 361012,Fujian,China)

机构地区：[1]厦门市仙岳医院,厦门医学院附属仙岳医院,福建省精神医学中心,福建省精神疾病临床医学研究中心住院部,福建厦门361012 [2]厦门市仙岳医院,厦门医学院附属仙岳医院,福建省精神医学中心,福建省精神疾病临床医学研究中心院办公室,福建厦门361012

出　　处：《中国现代医生》2024年第21期108-110,121,共4页China Modern Doctor

基　　金：厦门市医疗卫生指导性项目(3502Z20214ZD1283)。

摘　　要：目的探讨盐酸氟西汀胶囊和草酸艾司西酞普兰片治疗首发抑郁症的临床疗效。方法选取2023年2月至11月在厦门市仙岳医院中西医结合14病区住院的80例首发抑郁症患者,根据随机数字表法将患者分为盐酸氟西汀胶囊组(n=40)和草酸艾司西酞普兰片组(n=40);治疗前与治疗4周后对患者进行汉密顿抑郁量表(Hamilton depression scale,HAMD)评估,分析药物的临床治疗效果。结果药物治疗4周后,两组患者的HAMD评分均较本组治疗前显著降低(P<0.01);两组间比较差异无统计学意义(P>0.05)。两组患者的总有效率比较,差异无统计学意义(P>0.05)。结论草酸艾司西酞普兰片与盐酸氟西汀胶囊治疗首发抑郁症患者均有效,两组患者的总有效率相近。Objective To explore the clinical efficacy of fluoxetine hydrochloride capsules and escitalopram oxalate tablets in the treatment of first-episode depression disorder.Methods Eighty patients with first-episode depression disorder who were hospitalized in the 14th district of Integrated Traditional Chinese and Western Medicine of Xiamen Xianyue Hospital from February to November 2023 were selected,and divided into fluoxetine hydrochloride capsules group(n=40)and escitalopram oxalate tablets group(n=40)according to random number method;Conducted the Hamilton depression scale(HAMD)estimates before treatment and four weeks after treatment,to analyze and compare the clinical efficacy of two groups.Results After four weeks of treatment,the HAMD scores of all patients significantly decreased compared to before treatment in this group(P<0.01);There was no statistically significant difference between two groups(P>0.05).There was no statistically significant difference in the total effective rate between two groups(P>0.05).Conclusion Escitalopram oxalate tablets and fluoxetine hydrochloride capsules were both effective in treatment of the first-episode depression disorder patients,and the total effective rates of them were similar.

关 键 词：首发抑郁症 草酸艾司西酞普兰片 盐酸氟西汀胶囊 临床疗效 

分 类 号：R749[医药卫生—神经病学与精神病学]