血清金属硫蛋白1H、巨噬细胞移动抑制因子对骨肉瘤患儿免疫靶向治疗疗效的评估价值  

Value of serum metallothionein 1H and macrophage migration inhibitory factor H in evaluating the efficacy of immunotargeted therapy for children with osteosarcoma

作　　者：宋东建[1,2] 甘君龄 苏萌 刘秋亮[1] SONG Dongjian;GAN Junling;SU Meng;LIU Qiuliang(Department of Pediatric Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China;Institute of Molecular Cancer Surgery,Zhengzhou University,He’nan Province Engineering Research Center,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州大学第一附属医院小儿外科,郑州450000 [2]郑州大学肿瘤分子外科研究所,河南省肿瘤分子外科工程研究中心,郑州450000

出　　处：《癌症进展》2024年第12期1305-1308,共4页Oncology Progress

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200323);河南省中青年卫生健康科技创新优秀青年人才培养项目(YXKC2021060);河南省高等学校重点科研项目(20B320023)。

摘　　要：目的探讨血清金属硫蛋白1H(MT1H)、巨噬细胞移动抑制因子(MIF)对骨肉瘤(OS)患儿免疫靶向治疗疗效的评估价值。方法选取52例OS患儿,均采取α干扰素联合贝伐珠单抗治疗,治疗前、治疗12周后检测OS患儿的血清MT1H、MIF水平。记录OS患儿的治疗效果,将完全缓解和部分缓解患儿纳入有效组,疾病稳定和疾病进展患儿纳入无效组。比较有效组和无效组患儿的临床特征,采用Logistic回归模型分析OS患儿免疫靶向治疗疗效的影响因素。结果治疗12周后,OS患儿血清MT1H、MIF水平均明显低于治疗前,差异均有统计学意义(P﹤0.01)。52例患儿中,治疗有效35例,治疗无效17例。有效组患儿治疗后碱性磷酸酶(ALP)、MT1H、MIF水平均低于无效组,差异均有统计学意义(P﹤0.05)。多因素Logistic回归分析结果显示,治疗后ALP、MT1H、MIF高水平均是OS患儿免疫靶向治疗疗效的独立危险因素(P﹤0.05)。结论血清MT1H和MIF水平对OS患儿免疫靶向治疗疗效具有重要的评估价值,可为临床治疗方案的制订提供一定依据。Objective To investigate the value of serum metallothionein 1H(MT1H)and macrophage migration in-hibitory factor(MIF)in evaluating the efficacy of immunotargeted therapy for children with osteosarcoma.Method A total of 52 children with OS were selected,all patients were treated with interferon-αcombined with bevacizumab.The se-rum MT1H and MIF levels of children with OS were detected before and 12 weeks after treatment.The therapeutic effect of children with OS was recorded,and the children with complete response and partial response were included in the ef-fective group,and the children with stable disease and disease progressive were included in the ineffective group.The clinical characteristics of children in the effective group and the ineffective group were compared,and the factors influ-encing the efficacy of immunotargeted therapy in children with OS were analyzed by Logistic regression model.Result After 12 weeks of treatment,the serum MT1H and MIF levels of children with OS were significantly lower than those be-fore treatment,and the differences were statistically significant(P<0.01).Among 52 cases,35 cases were effective and 17 cases were ineffective.After treatment,the levels of alkaline phosphatase(ALP),MT1H and MIF in the effective group were lower than those in the ineffective group,and the differences were statistically significant(P<0.05).Multivariate Lo-gistic regression analysis showed that higher ALP,MT1H and MIF levels after treatment were independent risk factors for the efficacy of immunotargeted therapy in children with OS(P<0.05).Conclusion Serum MT1H and MIF levels have important reference value for evaluating the efficacy of immunotargeted therapy in children with OS,and can pro-vide a certain basis for the formulation of clinical treatment plan.

关 键 词：金属硫蛋白1H 巨噬细胞移动抑制因子 骨肉瘤 免疫靶向治疗 疗效 

分 类 号：R738.1[医药卫生—肿瘤]