聚乙烯醇载药微球介入栓塞在原发性肝癌患者中的应用效果  

Application effect of interventional embolization of polyvinyl alcohol-loaded microspheres in patients with primary liver cancer

作　　者：林亚超 许立国[1] 黄文浩[1] 冯广森[1] LIN Yachao;XU Liguo;HUANG Wenhao;FENG Guangsen(Department of Intervention,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,He’nan,China)

机构地区：[1]郑州大学第二附属医院介入科,郑州450003

出　　处：《癌症进展》2024年第12期1327-1330,共4页Oncology Progress

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20230350)。

摘　　要：目的探讨聚乙烯醇载药微球介入栓塞在原发性肝癌患者中的应用效果。方法将182例原发性肝癌患者按照治疗方法的不同分为对照组(n=87,传统栓塞治疗)和试验组(n=95,聚乙烯醇载药微球介入栓塞治疗),比较两组患者的临床疗效、血清学指标[甲胎蛋白(AFP)、总胆红素(TBIL)、丙氨酸转氨酶(ALT)]、不良反应发生情况及生存情况。结果治疗后3个月,两组患者AFP、TBIL、ALT水平均低于本组治疗前,试验组患者AFP、TBIL、ALT水平均低于对照组,差异均有统计学意义(P﹤0.05)。试验组患者客观缓解率和1年生存率均高于对照组,1级无症状或轻度体征发生率高于对照组,3、4级不良反应发生率均低于对照组,差异均有统计学意义(P﹤0.05)。结论聚乙烯醇载药微球介入栓塞治疗原发性肝癌的临床疗效较好,不良反应和对肝组织的损伤较小,并且能有效降低血清AFP水平,提高患者的生存率。Objective To investigate the application effect of interventional embolization of polyvinyl alcohol-loaded microspheres in patients with primary liver cancer.Method A total of 182 patients with primary liver cancer were divid-ed into control group(n=87,conventional embolization treatment)and experimental group(n=95,polyvinyl alcohol-load-ed microspheres interventional embolization treatment)according to different treatment methods,and the clinical effica-cy,serum indexes[α-fetoprotein(AFP),total bilirubin(TBIL),alanine aminotransferase(ALT)],incidence of adverse re-actions and survival were compared between the two groups.Result At 3 months after treatment,the AFP,TBIL and ALT levels in two groups were lower than those before treatment,the AFP,TBIL and ALT levels in experimental group were lower than those in control group,and the differences were statistically significant(P<0.05).The objective response rate and 1-year survival rate in experimental group were higher than those in control group,the incidence of grade 1 as-ymptomatic or mild signs was higher than that in control group,the incidence of grade 3 and 4 adverse reactions were lower than those in control group,and the differences were statistically significant(P<0.05).Conclusion Interventional embolization of polyvinyl alcohol-loaded microspheres has good clinical efficacy in the treatment of primary liver cancer,with less adverse reactions and damage to liver tissue.It can effectively reduce the level of serum AFP and improve the survival rate of patients.

关 键 词：聚乙烯醇载药微球 介入栓塞 原发性肝癌 应用效果 

分 类 号：R735.7[医药卫生—肿瘤]