儿童青少年抑郁障碍非自杀性自伤行为与脂代谢的关联研究  

Association between non-suicidal self-injury behavior and lipid metabolism in children and adolescents with depressivedisorder

作　　者：孙锋 蒋光明[1] 李冠军[2] 郭茜[2] 陈海莹[2] 姚高峰 崔舒 Sun Feng;Jiang Guangming;Li Guanjun;Guo Qian;Chen Haiying;Yao Gaofeng;Cui Shu(Psychiatry Department,Fuyang Third People's Hospital,Fuyang 236000,China;Third Clinical Department,Shanghai Mental Health Center,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China)

机构地区：[1]阜阳市第三人民医院精神科,236000 [2]上海交通大学医学院附属精神卫生中心临床三科,200030

出　　处：《神经疾病与精神卫生》2024年第7期472-476,共5页Journal of Neuroscience and Mental Health

基　　金：阜阳市卫生健康委科研紧缺专业项目(FY2023-136)。

摘　　要：目的 探讨儿童青少年抑郁障碍患者非自杀性自伤(NSSI)行为与脂代谢的关系。方法 回顾性选取2020年4月—2021年12月在阜阳市第三人民医院住院的681例儿童青少年抑郁障碍患者为研究对象,将患者分为伴NSSI组(n=254)和不伴NSSI组(n=427)。比较两组患者的一般资料和脂代谢水平,采用二项Logistic回归分析儿童青少年抑郁障碍患者发生非自杀性自伤(NSSI)行为的相关因素。结果 两组患者性别、发病年龄、总病程、文化程度、体重指数和高密度脂蛋白胆固醇(HDL-C)比较,差异均有统计学意义(均P<0.05)。二项Logistic回归分析显示,女性、体重指数高、HDL-C高是儿童青少年抑郁障碍患者发生NSSI行为的危险因素(OR>1,P<0.05),发病年龄大是患者发生NSSI行为的保护因素(OR<1,P<0.01)。结论 儿童青少年抑郁障碍患者NSSI行为与性别、发病年龄、HDL-C和体重指数相关。Objective To explore the association between non-suicidal self-injury(NSSI)behavior and lipid metabolism in children and adolescents with depressive disorder.Methods A retrospective study was conducted on 681 children and adolescents with depressive disorder who were hospitalized at the Fuyang Third People's Hospital from April 2020 to December 2021.The patients were divided into a group with NSSI(n=254)and a group without NSSI(n=427).The general information and lipid metabolism of two groups of patients were compared,and binomial Logistic regression was used to analyze the related factors of NSSI behavior in children and adolescents with depressive disorder.Results The differences in gender,age of onset,total course of disease,educational level,body mass index(BMI),and high-density lipoprotein cholesterol(HDL-C)between the two groups of patients were statistically significant(all P<0.05).Binomial Logistic regression analysis showed that women,high BMI,and high HDL-C were risk factors for NSSI behavior in children and adolescents with depressive disorder(OR>1,P<0.05),while older onset age was a protective factor for NSSI behavior(OR<1,P<O.01),and the differences were statistically significant.Conclusions NSSI behavior in children and adolescents with depressive disorder is associated with gender,age of onset,HDL-C,and BMI.

关 键 词：儿童 青少年 抑郁障碍 非自杀性自伤 脂代谢 

分 类 号：R749.4[医药卫生—神经病学与精神病学]