Commentary:brain endothelial GSDMD as a novel target for brain disorders associated with BBB damage  

作　　者：LIU Kui PANG Tao 

机构地区：[1]State Key Laboratory of Natural Medicines,New Drug Screening and Pharmacodynamics Evaluation Center,China Pharmaceutical University,Nanjing 210009,China

出　　处：《Chinese Journal of Natural Medicines》2024年第7期580-581,共2页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82174010 and 81973512).

摘　　要：The blood-brain barrier(BBB)is a highly selective and critical interface between the blood and the central nervous system(CNS),essential for maintaining the microenvironment necessary for normal brain function and homeostasis[1].The BBB is primarily formed by brain endothelial cells(bECs),pericytes,and astrocytes,and it operates in concert with microglia/macrophages and neurons[2,3]to constitute the neurovascular unit(Fig.1).Disruption of the BBB or the presence of systemic inflammation can precipitate or exacerbate various CNS pathologies,including Alzheimer’s disease[4],amyotrophic lateral sclerosis[5],Huntington’s disease[6]and multiple sclerosis.

关 键 词：Brain endothelial cells GSDMD Blood-brain barrier Natural products NEUROINFLAMMATION Brain disorders 

分 类 号：R965[医药卫生—药理学]