溃疡性结肠炎患者血清CXCL16、CCL20与炎症因子和黏膜愈合的关系  

Relationship between serum CXCL16,CCL20 and inflammatory factors and mucosal healing in patients with ulcerative colitis

作　　者：蔡涛 张婷 刘银奎 邓爽 唐闯 CAI Tao;ZHANG Ting;LIU Yinkui;DENG Shuang;TANG Chuang(Endoscopy Center,Chengdu Shuangliu District First People′s Hospital/West China Airport Hospital of Sichuan University,Chengdu,Sichuan 610000,China;Department of Gastroenterology,Chengdu Shuangliu District Traditional Chinese Medicine Hospital,Chengdu,Sichuan 610000,China)

机构地区：[1]成都市双流区第一人民医院/四川大学华西空港医院内镜中心,四川成都610000 [2]成都市双流区中医医院消化内科,四川成都610000

出　　处：《国际检验医学杂志》2024年第15期1799-1804,1810,共7页International Journal of Laboratory Medicine

基　　金：2020年四川省卫生健康委员会科研课题普及应用项目(20PJ0232)。

摘　　要：目的探讨溃疡性结肠炎(UC)患者血清CXC型趋化因子配体16(CXCL16)、趋化因子配体20(CCL20)与炎症因子和黏膜愈合的关系。方法选取2021年1月至2022年10月成都市双流区第一人民医院/四川大学华西空港医院收治的UC患者170例作为研究组,另选取同期在该院体检的健康者100例作为对照组。比较两组血清CXCL16、CCL20与炎症因子[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]水平,并分析UC患者血清CXCL16、CCL20与炎症因子的相关性。根据UC患者治疗后黏膜愈合预后情况分为愈合良好组和愈合不良组,比较不同预后患者血清CXCL16、CCL20水平。采用单因素及多因素Logistic回归分析模型分析UC患者治疗后黏膜愈合不良的危险因素,并采用受试者工作特征(ROC)曲线分析血清CXCL16、CCL20对UC患者治疗后黏膜愈合不良的预测价值。结果研究组血清CXCL16、CCL20、IL-1β、IL-6、TNF-α、IL-17及CRP水平显著高于对照组,差异有统计学意义(P<0.05)。Pearson相关分析显示,UC患者血清CXCL16、CCL20分别与IL-1β、IL-6、TNF-α、IL-17及CRP呈正相关(P<0.05),血清CXCL16与CCL20呈正相关(P<0.05)。愈合不良组血清CXCL16、CCL20水平显著高于愈合良好组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,CXCL16水平升高、CCL20水平升高、饮酒史、病情分级重度、红细胞沉降率(ESR)水平升高、CRP水平升高是UC患者治疗后黏膜愈合不良的危险因素(P<0.05)。ROC曲线结果显示,血清CXCL16、CCL20联合检测预测UC患者治疗后黏膜愈合不良的曲线下面积(AUC)较大,血清CXCL16、CCL20联合ESR、CRP预测UC患者治疗后黏膜愈合不良的AUC最大。结论UC患者血清CXCL16、CCL20水平与炎症因子密切相关,且联合检测对UC患者治疗后黏膜愈合不良具有较高的预测价值。Objective To investigate the relationship between serum chemokine C-X-C-motif ligand 16(CXCL16),CC chemokine ligand 20(CCL20)and inflammatory factors and mucosal healing in patients with ulcerative colitis(UC).Methods A total of 170 UC patients admitted to Chengdu Shuangliu District First People′s Hospital/West China Airport Hospital of Sichuan University from January 2021 to October 2022 were selected as the study group,and 100 healthy subjects who underwent physical examination in the hospital during the same period were selected as the control group.The levels of serum CXCL16,CCL20 and inflammatory factors[interleukin-1β(IL-1β),interleukin-6(IL-6),interleukin-17(IL-17),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]in the two groups were compared.The correlation between serum CXCL16,CCL20 and inflammatory factors in UC patients was analyzed.According to the prognosis of mucosal healing after treatment,UC patients were divided into good healing group and poor healing group.Serum CXCL16 and CCL20 levels of patients with different prognosis were compared.Univariate and multivariate Logistic regression analysis models were used to analyze the risk factors of poor mucosal healing in UC patients after treatment,and the predictive value of serum CXCL16 and CCL20 in poor mucosal healing in UC patients after treatment was analyzed by receiver operating characteristic(ROC)curve.Results The levels of serum CXCL16,CCL20,IL-1β,IL-6,TNF-α,IL-17 and CRP in the study group were significantly higher than those in the control group,with statistical significance(P<0.05).Pearson correlation analysis showed that serum CXCL16 and CCL20 were positively correlated with IL-1β,IL-6,TNF-α,IL-17 and CRP in UC patients,respectively(P<0.05),and serum CXCL16 was positively correlated with CCL20(P<0.05).The levels of CXCL16 and CCL20 in poor healing group were significantly higher than those in good healing group,and the difference was statistically significant(P<0.05).Multifactor Logistic regression analysis showed that in

关 键 词：溃疡性结肠炎 CXC型趋化因子配体16 趋化因子配体20 炎症因子 预后 

分 类 号：R574.62[医药卫生—消化系统]