Endoglin在前列腺癌研究中的临床意义  

Clinical significance of Endoglin in prostate cancer research

作　　者：杨辉 张鸿毅[1] 李华锋(综述) 赵刚刚(审校)[1] YANG Hui;ZHANG Hongyi;LI Huafeng;ZHAO Ganggang(Department of Urology,the First Affiliated Hospital of Xi′an Medical College,Xi′an,Shaanxi 710077,China)

机构地区：[1]西安医学院第一附属医院泌尿外科,陕西西安710077

出　　处：《国际检验医学杂志》2024年第15期1887-1890,共4页International Journal of Laboratory Medicine

摘　　要：前列腺癌是男性泌尿生殖系统常见的恶性肿瘤之一,是欧美国家男性人口死亡的主要原因之一,我国前列腺癌发病率呈上升趋势,前列腺癌治疗的关键为早期诊断与早期治疗。Endoglin又称内皮糖蛋白,是最可靠的内皮细胞增殖标志物,其在肿瘤新生血管中过度表达。肿瘤患者血清中发现可溶性Endoglin,可用于辅助诊断。通过抑制Endoglin受体可以抑制肿瘤血管的形成,为靶向治疗提供依据。Endoglin标记的微血管密度对实体瘤临床病理分级有重要意义,可用于预后评估。该文针对Endoglin在前列腺癌的发病,诊断治疗及预后方面予以综述。Prostate cancer is one of the most common malignant tumors in male genitourinary system,and it is one of the main causes of male death in Europe and America.The incidence of prostate cancer in our country is increasing,the key of treatment of prostate cancer is early diagnosis and early treatment.Endoglin also known as endothelial glycoprotein,is the most reliable marker of endothelial cell proliferation,which is overexpressed in neovascularization.Soluble Endoglin was found in the serum of tumor patients,which can be used as an auxiliary diagnosis.Inhibition of Endoglin receptor can inhibit the formation of tumor blood vessels,which provides a basis for targeted therapy.Microvessel density marked by Endoglin is of great significance in the clinical and pathological grading of solid tumors and can be used to evaluate the prognosis.This article reviews the role of Endoglin in the pathogenesis,diagnosis,treatment and prognosis of prostate cancer.

关 键 词：前列腺癌 ENDOGLIN 早期诊断 靶向治疗 

分 类 号：R737.25[医药卫生—肿瘤]