“从气守神”推拿法治疗广泛性焦虑症患者的临床疗效及对血清5-羟色胺、P物质的影响  

Clinical Effect of Qi-following and Spirit-maintaining Massage in Treatment of Generalized Anxiety Disorder and Its Influence on Serum 5-Hydroxytryptamine and Substance P

作　　者：张静[1] 李伟彪 王雪霞[2] 董升[2] 桑亚男[2] 詹巍 郭现辉[1,2] ZHANG Jing;LI Weibiao;WANG Xuexia;DONG Sheng;SANG Yanan;ZHAN Wei;GUO Xianhui(Henan University of Chinese Medicine,Henan Zhengzhou 450000,China;The Third Affiliated Hospital of Henan University of Chinese Medicine,Henan Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,河南郑州450000 [2]河南中医药大学第三附属医院,河南郑州450000

出　　处：《安徽中医药大学学报》2024年第4期60-65,共6页Journal of Anhui University of Chinese Medicine

基　　金：河南省“双一流”创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-09)。

摘　　要：目的观察“从气守神”推拿法对广泛性焦虑症(generalized anxiety disorder,GAD)的治疗效果及对血清5-羟色胺(5-hydroxytryptamine,5-HT)、P物质(substance P,SP)水平的影响。方法将58例GAD患者随机分为试验组和对照组,每组29例;试验组采用“从气守神”推拿法治疗,对照组采用常规推拿法治疗。比较两组患者治疗前后汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、焦虑自评量表(self-rating anxiety scale,SAS)、肝气郁结型中医证候量表、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)量表评分,血清5-HT、SP水平。结果试验组临床疗效优于对照组(P<0.05)。治疗后两组患者HAMA、SAS、肝气郁结证中医证候量表及PSQI量表评分均较治疗前显著减少(P<0.05);试验组HAMA、SAS及PSQI量表评分较对照组显著减少(P<0.05)。与治疗前比较,两组患者治疗后血清5-HT水平均显著升高(P<0.05),SP水平均显著降低(P<0.05),试验组升高和降低程度较对照组更显著(P<0.05)。结论“从气守神”推拿法可调节GAD患者血清5-HT、SP水平,调节脑—肠轴,从而有效改善患者情绪焦虑、失眠等临床症状。Objective To investigate the clinical effect of Qi-following and spirit-maintaining massage in the treatment of generalized anxiety disorder(GAD)and its influence on the serum levels of 5-hydroxytryptamine(5-HT)and substance P(SP).Methods A total of 58 patients with GAD were randomly divided into experimental group and control group,with 29 patients in each group.The patients in the experimental group received Qi-following and spirit-maintaining massage,and those in the control group received conventional massage.The two groups were compared in terms of Hamilton Anxiety Scale(HAMA),self-rating anxiety scale(SAS),TCM syndrome scale of stagnation of liver Qi,Pittsburgh Sleep Quality Index(PSQI)score,and the serum levels of 5-HT and SP before and after treatment.Results The experimental group had a significant better clinical outcome than the control group(P<0.05).After treatment,both groups had significant reductions in the scores of HAMA,SAS,TCM syndrome scale of stagnation of liver Qi,and PSQI(P<0.05),and compared with the control group,the experimental group had significantly lower HAMA,SAS,and PSQI scores(P<0.05).After treatment,both groups had a significant increase in the serum level of 5-HT and a significant reduction in the serum level of SP(P<0.05),and the experimental group had significantly greater changes than the control group(P<0.05).Conclusion For patients with GAD,Qi-following and spirit-maintaining massage can regulate the serum levels of 5-HT and SP and the brain-gut axis,thereby effectively improving the clinical symptoms of anxious emotion and sleep.

关 键 词：广泛性焦虑症 “从气守神”推拿法 5-羟色胺 P物质 

分 类 号：R749.72[医药卫生—神经病学与精神病学] R244.1[医药卫生—临床医学]