临床局限性前列腺癌术后包膜侵犯研究进展  

Research progress on capsular invasion after surgery for clinically localized prostatic cancer

作　　者：姜庆 徐苓傈 李丽[2] 李玉芬[2] JIANG Qing;XU Lingli;LI Li;LI Yufen(Department of Urology,Shang Jin Hospital of West China Hospital,Sichuan University,Chengdu 611700,China)

机构地区：[1]四川大学华西医院上锦医院成都上锦南府医院泌尿外科,四川成都611700 [2]四川大学华西医院泌尿外科,四川成都610041

出　　处：《陕西医学杂志》2024年第8期1135-1138,共4页Shaanxi Medical Journal

基　　金：国家自然科学基金资助面上项目(81672552)。

摘　　要：前列腺癌(PCa)是男性泌尿系统常见的恶性肿瘤。随着我国人口老龄化,PCa发病率逐年升高,且确诊时前列腺特异性抗原高、中高危人群占比较高。目前PCa治疗包括PCa根治术、去势、药物及外照射等,而PCa根治术是治疗临床局限性PCa最有效的方法,但部分临床局限性PCa患者术后病理提示包膜侵犯,在甲状腺外器官侵犯及远处淋巴结或远处器官组织转移中起到重要作用,被认为是术后生化复发和不良预后的预测因子。因此,现就临床局限性PCa术后包膜侵犯的定义、预后、影响因素以及不同影像学检查对其诊断的优势和不足等进行综述。Prostatic cancer(PCa)is a common malignancy of male urinary system.With aging of population in China,the incidence of PCa is increasing year by year.Prostate-specific antigen is high and the proportion of middle to high risk group is relatively high at confirmed diagnosis.At present,treatments for PCa include radical resection of PCa,castration,drugs and external irradiation,and radical resection of PCa is the most effective method for treating clinically localized PCa.However,postoperative pathology indicates that some patients with clinically localized PCa have capsular invasion,which plays an important role in extra-thyroid organ invasion and distant lymph node or distant organ/tissue metastasis.It is considered to be a predictor of postoperative biochemical recurrence and poor prognosis.Herein,this article reviews the definition,prognosis and influencing factors of capsular invasion after surgery for clinically localized PCa,and the advantages and disadvantages of different imaging examinations in its diagnosis.

关 键 词：局限性前列腺癌 前列腺癌根治术 包膜侵犯 预后 影响因素 影像学检查 

分 类 号：R737.25[医药卫生—肿瘤]