多功能金纳米粒子的构建及其在癌症诊疗中的应用  

Construction of Multifunctional Gold Nanoparticles and Their Application in Cancer Diagnosis and Treatment

作　　者：王艺洁 胡怡萱 孙毓琛 弓韬[1] 郭睿[1] WANG Yi-jie;HU Yi-xuan;SUN Yu-chen;GONG Tao;GUO Rui(School of Basic Medicine,Shanxi Medical University,Taiyuan 030001,China;School of Second Clinical Medical,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学基础医学院,山西太原030001 [2]山西医科大学第二临床医学院,山西太原030001

出　　处：《化学试剂》2024年第8期10-18,共9页Chemical Reagents

基　　金：国家自然科学基金项目(32300641);山西省自然科学研究面上项目(202103021224240);细胞生理学教育部重点实验室山西医科大学开放基金项目(CPOF202307)。

摘　　要：癌症是全球面临的重大健康问题之一,有效的癌症筛查和早诊早治是提高癌症患者生存率、降低死亡率的重要途径,也是推动癌症科学防治的有效手段。近年来,金纳米粒子因其优良的生物相容性、光热性能和低毒性而受到越来越多的关注。经过多功能修饰的金纳米粒子可以主动靶向于肿瘤细胞,还可通过光热疗法、光动力疗法和化学疗法联合治疗癌症。此外,金纳米粒子的光学特性使其在生物成像方面也发挥了重要作用。基于先前对金纳米粒子的研究,系统总结了多功能金纳米粒子复合材料在癌症诊断与治疗方面的最新进展,讨论了金纳米粒子未来在抗肿瘤方面的发展前景。Cancer is one of the significant health problems confronting the world.Valid cancer screening and early diagnosis and treatment are important avenues to improve the survival rate and reduce the mortality rate of cancer patients,as well as effective methods to advance the scientific prevention and treatment of cancer.In recent years,gold nanoparticles(GNPs)have attracted more and more attention due to their exceptional biocompatibility,photothermal properties and hypotoxicity.GNPs can be modified with multiple functions,which allows them to actively target cancer cells and treat the disease through a combination of photothermal therapy,photodynamic therapy and chemotherapy.In addition,GNPs also play an important role in biological imaging because of their optical characteristics.Based on previous researches on GNPs,the latest progress of multifunctional GNPs composites in cancer diagnosis and therapy was systematically summarized,and the future prospects of GNPs in anti-tumor were discussed.

关 键 词：金纳米粒子 药物载体 联合治疗 生物成像 癌症 

分 类 号：R73[医药卫生—肿瘤]