循环肿瘤DNA与胃肠道恶性肿瘤相关研究的文献计量分析  

Bibliometric analysis of studies on the association of circulating tumor DNA with gastrointestinal malignancies

作　　者：韩永东 郑宜鋆 赵嵩博 王哲元[1,2] 张有成[1,2] Han Yongdong;Zheng Yijun;Zhao Songbo;Wang Zheyuan;Zhang Youcheng(The Second Clinical Medical School,Lanzhou University,Lanzhou 730030,China;Department of General Surgery,The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二临床医学院,甘肃兰州730030 [2]兰州大学第二医院普通外科,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2024年第6期67-76,共10页Journal of Lanzhou University（Medical Sciences）

基　　金：甘肃省高等学校产业支撑资助项目(2023CYZC-05);兰州大学第二医院2022年“萃英科技创新”计划资助项目(CY2022-MS-B04)。

摘　　要：目的利用文献计量学分析工具分析循环肿瘤DNA与胃肠道恶性肿瘤的相关研究,探讨该领域的研究现状、热点分布和未来趋势。方法检索建库至2023年11月17日的Web of Science核心合集数据库,使用CiteSpace 6.2.R6、Scimago Graphica、VOSviewer 1.6.19和R软件(Bibliometrix包)用于数据分析和可视化。结果纳入语种为英文的论著和综述共1326篇,1997—2014年为研究成果缓慢增长期,2014年以后发文量快速增长。国家(地区)和机构合作分析表明美国和西欧是该领域的全球研究中心,美国德克萨斯大学是发文量最多的机构。发文量最多的学者是Bardelli Alberto,被引频次最多的学者是Chetan Bettegowda。《Cancers》是载文量最高的期刊,该领域呈现出突变分析向临床应用发展的趋势,突变分析相关的热点包括微卫星不稳定、启动子甲基化、KRAS基因突变、拷贝数畸变、表皮生长因子受体、肿瘤内异质性,临床应用方面备受关注的热点涉及诊断、疗效监测、获得性耐药、复发风险、微小残留疾病监测。结论该领域的研究方兴未艾,整体上呈现出从全基因组测序到精准靶向测序、将突变分析与临床实践相结合的趋势。Objective Studies related to ctDNA and gastrointestinal malignancies were sorted out by bibliometric analysis tools,and the current status of research,distribution of hotspots,and future trends in the field were discussed.Methods The Web of Science Core Collection(WOSCC) database was searched up to 17November 2023.CiteSpace 6.2.R6,Scimago Graphica,VOSviewer 1.6.19,and R software(Bibliometrix package) were used for data analysis and visualization.Results The study included a total of 1 326 articles and reviews in English,with a period of slow growth in research output from 1997—2014 and a rapid increase in the number of publications after 2014.The analysis of national(regional) and institutional collaborations showed that the United States and Western Europe were the global research centers in the field,and the University of Texas,USA was the institution with the most number of publications.The scholar with the highest number of publications was Bardelli Alberto and the scholar with the highest number of citations was Chetan Bettegowda.Cancers was the journal with the highest number of articles.The field is showing a trend of mutation analysis towards clinical practice.Hot topics related to mutation analysis include microsatellite instability,promoter methylation,KRAS mutations,copy number aberrations,epidermal growth factor receptor,and intra-tumor heterogeneity.The hotspots of clinical application are related to diagnosis,efficacy monitoring,acquired drug resistance,recurrence risk,and monitoring of minimal residual disease.Conclusion Research in this field is in the ascendant,showing a trend from whole genome sequencing to precise targeted sequencing,combining sequence analysis with clinical practice.

关 键 词：胃肠道恶性肿瘤 循环肿瘤DNA 研究趋势 CITESPACE 文献计量分析 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]