结直肠癌组织中CDX-2、PMS2表达水平及对不同分期结直肠癌的诊断价值  

Expression Levels of CDX-2 and PMS2 in Colorectal Cancer Tissues and Their Diagnostic Value in Different Stages of Colorectal Cancer

作　　者：张娜娜 柴力佳 钟洁 ZHANG Na-na;CHAI Li-jia;ZHONG Jie(Department of Pathology,Zhumadian Central Hospital,Zhumadian,Henan 4630002;Department of Pathology,Zhumadian First People's Hospital,Zhumadian,Henan 463000)

机构地区：[1]河南省驻马店市中心医院病理科,河南驻马店463000 [2]河南省驻马店市第一人民医院病理科,河南驻马店463000

出　　处：《中国肛肠病杂志》2024年第6期1-4,共4页Chinese Journal of Coloproctology

摘　　要：目的:探讨结直肠癌组织中尾型同源盒转录因子-2(CDX-2)、错配修复蛋白(PMS2)的表达水平及对不同分期结直肠癌的诊断价值。方法:选取2019年1月至2024年1月,本院收治的90例结直肠癌患者为观察组,同期90例良性结直肠肿瘤患者为对照组。将观察组患者依照TNM分期分为Ⅰ期组21例,Ⅱ期组23例,Ⅲ期组28例和Ⅳ期组18例。所有患者肿瘤组织均行免疫组化染色,检测CDX-2、PMS2表达水平,采用Spearman相关性分析法分析CDX-2、PMS2与结直肠癌临床分期的相关性,并建立受试者工作特征(ROC)曲线,分析CDX-2、PMS2对不同分期结直肠癌的诊断效能。结果:观察组CDX-2、PMS2的阳性率明显高于对照组(P<0.05),结直肠癌Ⅰ期组CDX-2、PMS2阳性率明显低于Ⅱ期组、Ⅲ期组和Ⅳ期组(P<0.05)。Spearman分析显示CDX-2、PMS2与结直肠癌临床分期呈正相关(P<0.05),CDX-2对不同分期结直肠癌的诊断曲线下面积为0.622,灵敏度、特异度为61.00%和53.00%,PMS2对不同分期结直肠癌的诊断曲线下面积为0.675,灵敏度、特异度为65.00%和57.00%,两者联合的曲线下面积为0.832,诊断灵敏度与特异度均明显高于单一指标(P<0.05)。结论:结直肠癌组织中CDX-2、PMS2表达明显上调,且CDX-2、PMS2均对不同分期的结直肠癌具有一定诊断价值,临床可将两者结合为结直肠癌临床分期的判断提供参考。Objective To investigate the expression levels of CDX-2 and mismatch repair protein(PMS2)in colorectal cancer tissues and their diagnostic value in different stages of colorectal cancer.Methods Total 90 patients with colorectal cancer admitted to our hospital from January 2019 to January 2024 were selected as the observation group,and another 90 patients with benign colorectal tumors were selected as the control group during the same period.According to TNM stage,the observation group was divided into stageⅠgroup(21 cases),stageⅡgroup(23 cases),stageⅢgroup(28 cases)and stageⅣgroup(18 ca-ses).Immunohistochemical staining was performed on the tumor tissues of all patients to detect the ex-pression levels of CDX-2 and PMS2.Spearman correlation analysis was used to analyze the correlation be-tween CDX-2,PMS2 and the clinical stage of colorectal cancer,and receiver operating characteristic(ROC)curve was established to analyze the diagnostic efficacy of CDX-2 and PMS2 in different stages of colorectal cancer.Results The positive rate of CDX-2 and PMS2 in the observation group was significantly higher than that in the control group(P<0.05),and the positive rate of CDX-2 and PMS2 in colorectal cancer stageⅠgroup was significantly lower than that in stageⅡ,ⅢandⅣgroups(P<0.05).Spearman anal-ysis showed that CDX-2 and PMS2 were positively correlated with the clinical stages of colorectal cancer(P<0.05).The area under the diagnostic curve of CDX-2 for different stages of colorectal cancer was 0.622,and the sensitivity and specificity were 61.00%and 53.00%.The diagnostic area under the curve of PMS2 for different stages of colorectal cancer was 0.675,the sensitivity and specificity were 65.00%and 57.00%,and the combined area under the curve was 0.832,and the diagnostic sensitivity and specificity were significantly higher than that of single index(P<0.05).Conclusion The expression levels of CDX-2 and PMS2 in colorectal cancer tissues are significantly up-regulated.CDX-2 and PMS2 are of certain diagnostic value

关 键 词：结直肠癌 中尾型同源盒转录因子-2 错配修复蛋白 临床分期 诊断价值 

分 类 号：R735.34[医药卫生—肿瘤]