铁过载骨髓增生异常综合征患者白介素-17、白介素-6水平及其临床意义  

Levels and Clinical Significance of Interleukin-17 and Interleukin-6 in Patients with Iron Overload and Myelodysplastic Syndrome

作　　者：朱献光 刘慧芳[1] 杨梦然 陈冉 ZHU Xianguang;LIU Huifang;YANG Mengran(Henan Provincial People's Hospital,Zhengzhou,450000)

机构地区：[1]河南省人民医院,450000 [2]郑州市金水区总医院,450000

出　　处：《实用癌症杂志》2024年第8期1224-1227,共4页The Practical Journal of Cancer

摘　　要：目的分析铁过载骨髓增生异常综合征患者白介素-17、白介素-6水平及其临床意义。方法回顾分析150例骨髓增生异常综合征患者资料,根据患者血清铁蛋白水平分为铁过载组(血清铁蛋白>1000 ng/ml,88例)和非铁过载组(血清铁蛋白≤1000 ng/ml,62例),取同期75例健康体检者为对照组。比较3组白介素-17、白介素-6水平差异。依据国际预后积分系统(IPSS)将铁过载组患者分为低危亚组、中危亚组、高危亚组,比较3组白介素-17、白介素-6水平差异,使用Spearman相关系数分析白介素-17、白介素-6水平与预后相关性。结果3组白介素-17、白介素-6水平差异有统计学意义(P<0.05),铁过载组>非铁过载组>对照组。铁过载组三亚组白介素-17、白介素-6水平差异有统计学意义(P<0.05),高危亚组>中危亚组>低危亚组;Spearman相关系数显示白介素-17、白介素-6水平与IPSS正相关(P<0.05)。结论白介素-17、白介素-6水平与铁过载骨髓增生异常综合征发生发展均有关联,早期监测有助于预后评估。Objective To analyze the levels and clinical significance of interleukin-17 and interleukin-6 levels on prognosis in patients with iron overload and myelodysplastic syndrome.Methods The data of 150 patients with myelodysplastic syndrome were retrospectively analyzed.According to the level of serum ferritin,the patients were divided into iron overload group(serum ferritin>1000 ng/ml,88 cases)and non-iron overload group(serum ferritin≤1000 ng/ml,62 cases).75 healthy subjects with physical examination during the same period were selected as control group.The differences in levels of interleukin-17 and interleukin-6 were compared among the three groups.Patients in iron overload group were classified into low-risk subgroup,middle-risk subgroup and high-risk subgroup according to the International Prognosis Score System(IPSS),and the differences in interleukin-17 and interleukin-6 levels among the three subgroups were compared.The correlation between interleukin-17 and interleukin-6 levels and prognosis was analyzed by Spearman correlation coefficient.Results There were statistical differences in the levels of interleukin-17 and interleukin-6 among the 3 groups(P<0.05),and the levels were shown as iron overload group non-iron overload group control group.The levels of interleukin-17 and interleukin-6 in the 3 subgroups of iron overload group were statistically different(P<0.05),and the levels were manifested as high-risk subgroup middle-risk subgroup low-risk subgroup.Spearman correlation coefficient showed that the levels of interleukin-17 and interleukin-6 were positively correlated with IPSS(P<0.05).Conclusion Interleukin-17 and interleukin-6 levels are associated with the occurrence and development of iron overload and myelodysplastic syndrome,and early monitoring is helpful for prognosis assessment.

关 键 词：铁过载 骨髓增生异常综合征 白介素-17 白介素-6 预后 国际预后积分系统 

分 类 号：R733.3[医药卫生—肿瘤]