糖尿病合并胰腺癌患者血清及组织中c-myc和PTEN表达水平及其与预后的关系  

Expression Levels of c-myc and PTEN in Serum and Tissue of Diabetic Patients with Pancreatic Cancer and Their Relationship with Prognosis

作　　者：芦玉玉 陶玲玲 LU Yuyu;TAO Lingling(Zhengzhou Yihe Hospital,Zhengzhou,450000)

机构地区：[1]河南省郑州颐和医院,450000

出　　处：《实用癌症杂志》2024年第8期1235-1238,共4页The Practical Journal of Cancer

摘　　要：目的探讨糖尿病合并胰腺癌患者血清及组织中c-myc和PTEN表达水平及其与预后的关系。方法选取胰腺癌患者64例,其中单纯胰腺癌患者25例纳入对照组,将合并糖尿病患者39例纳入观察组。采用酶联免疫吸附法检测血清c-myc和PTEN水平。免疫组织化学法检测癌组织中c-myc和PTEN蛋白表达。统计2组血清及组织中c-myc和PTEN表达、生存情况,COX多因素回归分析影响糖尿病合并胰腺癌患者预后因素。结果观察组血清c-myc水平高于对照组,PTEN水平低于对照组,P<0.05;观察组癌组织中c-myc蛋白阳性率高于对照组,PTEN蛋白阳性率低于对照组,P<0.05。c-myc(+)患者生存率低于c-myc(-)患者生存率,PTEN(+)患者生存率高于PTEN(-)患者生存率,P<0.05。合并糖尿病、c-myc阳性表达、PTEN阳性表达、肿瘤大小、远处器官转移、分化程度是影响胰腺癌患者预后的独立因素(P<0.05)。结论糖尿病合并胰腺癌患者血清和组织中c-myc和PTEN表达水平异常,c-myc阳性表达与预后不良相关,PTEN阳性表达与预后良好相关。Objective To investigate the expression levels of c-myc and PTEN in serum and tissue of patients with diabetes mellitus complicated with pancreatic cancer and their relationship with prognosis.Methods 64 patients with pancreatic cancer were selected,of which 25 patients with simple pancreatic cancer were included in the control group and 39 patients with diabetes mellitus were included in the observation group.Serum c-myc and PTEN levels were detected by enzyme-linked immunosorbent assay.The expression of c-myc and PTEN proteins in cancer tissues was detected by immunohistochemistry.The expression and survival of c-myc and PTEN in serum and tissues of the 2 groups were analyzed.COX multivariate regression analysis was conducted to analyze the prognostic factors of diabetic patients with pancreatic cancer.Results The serum c-myc level in the observation group was higher than that in the control group,and the serum PTEN level was lower than that in the control group,P<0.05;The positive rate of c-myc protein in the observation group was higher than that in the control group,and the positive rate of PTEN protein was lower than that in the control group,P<0.05.The survival rate of c-myc(+)patients was lower than that of c-myc(-)patients,and the survival rate of PTEN(+)patients was higher than that of PTEN(-)patients,P<0.05;Diabetes mellitus,positive expression of c-myc,positive expression of PTEN,tumor size,distant organ metastasis and differentiation degree were independent factors affecting the prognosis of pancreatic cancer patients(P<0.05).Conclusion The expression levels of c-myc and PTEN are abnormal in serum and tissues of patients with diabetes complicated with pancreatic cancer.Positive expression of c-myc is associated with poor prognosis,and positive expression of PTEN is associated with good prognosis.

关 键 词：胰腺癌 糖尿病 C-MYC PTEN 预后 

分 类 号：R735.9[医药卫生—肿瘤]