超声内镜联合血清SCC、CA19-9检测对早期食管癌的诊断价值  

Diagnostic Value of Endoscopic Ultrasonography Combined with Serum SCC and CA19-9 in Detecting Early Esophageal Cancer

作　　者：李娟花 张坤 董亚丽 LI Juanhua;ZHANG Kun;DONG Yali(Henan Electric Power Hospital,Zhengzhou,450000)

机构地区：[1]河南电力医院,450000

出　　处：《实用癌症杂志》2024年第8期1253-1256,共4页The Practical Journal of Cancer

摘　　要：目的探讨超声内镜(EUS)联合血清鳞状细胞癌抗原(SCC)、糖类抗原19-9(CA19-9)检测在早期食管癌诊断中的应用价值。方法采用EUS探查60例疑似早期食管癌患者,同时应用全自动生化分析仪检测其血清SCC和CA19-9水平。以胃镜下咬检病理检查结果为金标准,分析EUS对早期食管癌的诊断准确性。将研究对象分为食管癌组、非食管癌组,比较两组血清SCC、CA19-9水平差异,并绘制受试者工作特征曲线(ROC)分析血清SCC、CA19-9水平的诊断准确性,及其联合EUS对早期食管癌的诊断效能。结果EUS诊断早期食管癌的准确性、特异性和敏感性依次为90.00%、90.48%、89.74%。与非食管癌组比较,食管癌组血清SCC、CA19-9水平较低(P<0.05)。绘制ROC曲线发现血清SCC、CA19-9诊断早期食管癌的AUC分别为0.705、0.714,截断值分别为0.52μg/L、45.21 U/ml,特异性分别为66.67%、71.79%,敏感性分别为71.43%、76.19%,均为早期食管癌的诊断因子。将患者血清SCC、CA19-9水平与EUS联合用于早期食管癌诊断,其AUC为0.960,特异性为94.87%,高于单一因子(P<0.05)。结论EUS联合血清SCC与CA19-9应用于诊断早期食管癌价值显著,可提高诊断准确性。Objective To explore the application value of endoscopic ultrasound(EUS)combined with serum squamous cell carcinoma antigen(SCC)and carbohydrate antigen 19-9(CA19-9)detection in early esophageal cancer screening.Methods EUS was used to detect 60 patients with suspected early esophageal cancer,and the serum SCC and CA19-9 levels were detected by automatic biochemical analyzer.Using the pathological examination results under gastroscopy as the gold standard,analyzed the diagnostic accuracy of EUS for early esophageal cancer.Divided the study subjects into esophageal cancer group and non esophageal cancer group,compared the differences in serum SCC and CA19-9 levels between the 2 groups,and draw the receiver operating characteristic curve(ROC)to analyze the diagnostic accuracy of serum SCC and CA19-9 levels,as well as the combined diagnostic efficacy of EUS for early esophageal cancer.Results The accuracy,specificity,and sensitivity of EUS in diagnosing early esophageal cancer were 90.00%,90.48%,and 89.74%,respectively.Compared with the non esophageal cancer group,the esophageal cancer group had lower levels of serum SCC and CA19-9(P<0.05).Drawing ROC curves revealed that the AUC values for serum SCC and CA19-9 screening for early esophageal cancer were 0.705 and 0.714,respectively,with cutoff values of 0.52μg/L and 45.21 U/ml,with specificity of 66.67%and 71.79%,sensitivity of 71.43%and 76.19%,respectively,they were diagnostic factors for early esophageal cancer.The combination of serum SCC and CA19-9 levels with EUS was used for early esophageal cancer screening in this group.The AUC was 0.960,with a specificity of 94.87%,which was higher than a single factor(P<0.05).Conclusion The application of EUS combined with serum SCC and CA19-9 in early esophageal cancer screening has significant diagnostic value and can improve diagnostic accuracy.

关 键 词：超声内镜 鳞状细胞癌抗原 糖类抗原19-9 早期 食管癌 诊断 特异性 敏感性 

分 类 号：R735.1[医药卫生—肿瘤]