血清MMP-9、IL-6对非小细胞肺癌患者电视辅助胸腔镜术后复发风险的预测分析  

Predictive Analysis of Serum MMP-9 and IL-6 on Recurrence Risk of Patients with Non-small Cell Lung Cancer After Video-assisted Thoracoscopic Surgery

作　　者：董玉倩 王亚南 DONG Yuqian;WANG Yanan(The First Affiliated Hospital of Xinxiang Medical College,Xinxiang,453000)

机构地区：[1]新乡医学院第一附属医院,453000

出　　处：《实用癌症杂志》2024年第8期1285-1289,共5页The Practical Journal of Cancer

摘　　要：目的探讨非小细胞肺癌(NSCLC)患者电视辅助胸腔镜(VATS)术前血清基质金属蛋白酶-9(MMP-9)、白细胞介素-6(IL-6)水平对术后复发的预测价值。方法前瞻性选择NSCLC患者98例作为研究对象。患者均接受VATS治疗,术后随访2年,以复发作为随访终点事件,记录复发情况,将复发患者纳入复发组,未复发患者纳入未复发组。患者术前均接受血清MMP-9、IL-6检查,分析血清MMP-9、IL-6对NSCLC患者VATS术后复发的预测价值。结果98例NSCLC患者VATS术后随访2年,期间复发29例,复发率为29.59%;复发组TNM分期Ⅱ~Ⅲ期占比、术前血清MMP-9、IL-6水平均高于未复发组,差异有统计学意义(P<0.05);血清MMP-9、IL-6水平与NSCLC患者VATS术后复发呈正相关,特别当血清MMP-9>421.715 ng/L、IL-6>11.025 ng/L时,NSCLC患者VATS术后复发风险随MMP-9、IL-6水平升高而升高;绘制ROC曲线,NSCLC患者VATS术前血清MMP-9、IL-6水平单独、联合预测术后复发的AUC均>0.70,有一定预测价值。结论NSCLC患者VATS术前血清MMP-9、IL-6水平可能是术后复发风险因子,可能对早期预测术后复发风险有一定价值。Objective To investigate the predictive value of preoperative serum matrix metalloproteinase-9(MMP-9)and interleukin-6(IL-6)levels on postoperative recurrence in patients with non-small cell lung cancer(NSCLC)undergoing video-assisted thoracoscopy(VATS).Methods 98 patients with NSCLC were prospectively selected as the study subjects.All patients received VATS treatment and were followed up for 2 years after operation.Recurrence was used as the end point of follow-up,and the recurrence was recorded.The patients with recurrence were included in the recurrence group,and the patients without recurrence were included in the non recurrence group.All patients were examined for serum MMP-9 and IL-6 before operation.The baseline data of patients were counted and the predictive value of serum MMP-9 and IL-6 for postoperative recurrence of VATS in patients with NSCLC was analyzed.Results 98 patients with NSCLC were followed up for 2 years after VATS.29 cases recurred during VATS.The recurrence rate was 29.59%.The proportion of patients with TNM stageⅡ~Ⅲand the levels of serum MMP-9 and IL-6 in the recurrence group were higher than those in the non recurrence group,the difference was statistically significant(P<0.05).The levels of serum MMP-9 and IL-6 were positively correlated with the recurrence of NSCLC patients after VATS.Especially when serum MMP-9>421.715 ng/L and IL-6>11.025 ng/L,the risk of recurrence of NSCLC patients after VATS increased with the increase of MMP-9 and IL-6 levels.The ROC curve was drawn.The AUC of serum MMP-9 and IL-6 levels in NSCLC patients before VATS alone and in combination to predict postoperative recurrence was>0.70,which had certain predictive value.Conclusion The serum levels of MMP-9 and IL-6 in NSCLC patients before VATS may be a risk factor for postoperative recurrence,which may have certain value in early prediction of postoperative recurrence risk.

关 键 词：非小细胞肺癌 电视辅助胸腔镜 基质金属蛋白酶-9 白细胞介素-6 复发 

分 类 号：R734.2[医药卫生—肿瘤]