肺癌七项自身抗体联合检测在肺结节良恶性鉴别诊断中的应用价值  

Application of Seven Autoantibodies Combined Detection for Lung Cancer in the Differential Diagnosis of Benign and Malignant Pulmonary Nodules

作　　者：侯卫科[1] HOU Weike(Henan Hongli Hospital,Changyuan,453400)

机构地区：[1]河南宏力医院,453400

出　　处：《实用癌症杂志》2024年第8期1297-1300,共4页The Practical Journal of Cancer

摘　　要：目的探讨肺癌七项自身抗体检测在肺结节良恶性鉴别诊断中的临床价值。方法选取肺癌患者45例作为观察组,另选同期收治的良性肺结节患者45例作为对照组,所有患者均采集血液进行抑癌基因53(p53)、干细胞转录因子2(SOX2)、肿瘤睾丸抗原7(GAGE7)、蛋白基因产物9.5(PGP9.5)、人癌抗原(Cage)、黑色素瘤抗原A1(MAGEA1)、肿瘤抗原4-5(Gbu4-5)检测,比较2组各抗体间差异;并依据肺癌肿瘤分期分为Ⅰ~Ⅱ、Ⅲ~Ⅳ期患者,比较2组各抗体间水平差异;绘制ROC曲线,分析各抗体及联合检测鉴别诊断良恶性肺结节的临床价值。结果观察组p53、SOX2、GAGE7、PGP9.5、Cage、MAGEA1、Gbu4-5水平高于对照组,差异有统计学意义(P<0.05)。45例肺癌患者中Ⅰ~Ⅱ期29例,Ⅲ~Ⅳ期16例;Ⅲ~Ⅳ期患者p53、SOX2、GAGE7、PGP9.5、Cage、MAGEA1、Gbu4-5水平高于Ⅰ~Ⅱ期患者,差异有统计学意义(P<0.05)。绘制ROC曲线显示,联合肺癌七项自身抗体检测鉴别诊断肺结节良恶性价值更高。结论肺癌七项自身抗体检测在肺结节良恶性鉴别诊断中价值高,可提高诊断灵敏度及特异度,有助于后续针对性治疗工作的开展。Objective To explore the clinical value of seven autoantibody tests for lung cancer in the differentiation of benign and malignant pulmonary nodules.Methods 45 lung cancer patients were selected as the observation group,and another 45 benign lung nodule patients were selected as the control group.All patients collected blood for testing of tumor suppressor gene 53(p53),stem cell transcription factor 2(SOX2),tumor testicular antigen 7(GAGE7),protein gene product 9.5(PGP9.5),human cancer antigen(Cage),melanoma antigen A1(MAGEA1)Tumor antigen 4-5(Gbu4-5)detection,compared the differences between the 2 groups of antibodies;According to the staging of lung cancer,patients were divided into stagesⅠ~ⅡandⅢ~Ⅳ,and the differences in antibody levels between the 2 groups were compared;Draw ROC curves,analyzed the clinical value of various antibodies and combined detection in differential diagnosis of benign and malignant pulmonary nodules.Results The levels of p53,SOX2,GAGE7,PGP9.5,Cage,MAGEA1,and Gbu4-5 in the observation group were significantly higher than those in the control group(P<0.05);Among 45 lung cancer patients,there were 29 cases in stageⅠ~Ⅱand 16 cases in stageⅢ~Ⅳ;The levels of p53,SOX2,GAGE7,PGP9.5,Cage,MAGEA1,and Gbu4-5 in patients with stageⅢ~Ⅳwere higher than those in patients with stageⅠ~Ⅱ,and the difference was statistically significant(P<0.05);Drawing ROC curves showed that combined detection has higher value in distinguishing between benign and malignant pulmonary nodules.Conclusion The seven autoantibody tests for lung cancer have high value in the differentiation of benign and malignant pulmonary nodules,which can improve diagnostic sensitivity and specificity,and facilitate the subsequent targeted treatment work.

关 键 词：肺结节 良恶性鉴别 肺癌七项自身抗体 ROC曲线 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤]