COL10A1、COLⅣ、Cry61表达对直肠癌患者预后的评估价值  

Prognostic Value of COL10A1,COLⅣand Cry61 Expression in Patients with Rectal Cancer

作　　者：孙正路 刘东亚 王航宇 SUN Zhenglu;LIU Dongya;ZHANG Hangyu(The First Affiliated Hospital of Henan University,Kaifeng,475000)

机构地区：[1]河南大学第一附属医院,475000

出　　处：《实用癌症杂志》2024年第8期1306-1310,共5页The Practical Journal of Cancer

基　　金：2023年开封市科技发展计划(编号:2303015)。

摘　　要：目的探究直肠癌患者血清X型胶原A1链(COL10A1)、Ⅳ型胶原(COLⅣ)、富含半胱氨酸蛋白61(Cry61)表达对直肠癌患者预后的评估价值。方法收集62例直肠癌患者临床资料。随访至2023年10月,观察预后情况,根据患者是否死亡分为不良组(n=12例)和良好组(n=50例)。比较两组性别、年龄、淋巴结转移、肿瘤分期、分化程度、COL10A1、COLⅣ、Cry61水平;分析直肠癌患者血清COL10A1、COLⅣ、Cry61水平与临床特征的关系。结果两组患者性别、年龄差异不显著(P>0.05),两组淋巴结转移、肿瘤分期、分化程度差异有统计学意义(P<0.05)。不良组COL10A1、COLⅣ、Cry61水平高于良好组,差异显著(P<0.05)。COL10A1、COLⅣ、Cry61水平与患者性别、年龄无关,与淋巴结转移、Ⅲ~Ⅳ期、低分化有关,淋巴结转移、Ⅲ~Ⅳ期、低分化者COL10A1、COLⅣ、Cry61水平显著高于无淋巴结转移、Ⅰ~Ⅱ期、中高分化患者,差异显著(P<0.05)。COL10A1、COLⅣ、Cry61三者联合检测对直肠癌预后的预测价值良好,AUC为0.863,灵敏度、特异度分别为0.917、0.760,三者联合相对单一指标预测效能较好。三者预测阈值分别为6.840 ng/ml、158.965 ng/ml、481.795 ng/l。结论COL10A1、COLⅣ、Cry61表达水平在直肠癌预后不良患者血清中呈现出显著的升高趋势。COL10A1、COLⅣ、Cry61三者联合对直肠癌预后不良有良好的评估价值。Objective To explore the prognostic value of serum expression of collagen X-A1(COL10A1),collagenⅣ(COLⅣ)and cysteine-rich 61(Cry61)in patients with rectal cancer.Methods Clinical data of 62 patients with rectal cancer were collected.The patients were followed up to October 2023 to observe the prognosis,and were divided into poor group(n=12 cases)and good group(n=50 cases)according to whether they survived.Gender,age,lymph node metastasis,tumor stage,degree of differentiation,COL10A1,COLⅣand Cry61 levels were compared between the two groups.To analyze the relationship between serum COL10A1,COLⅣ,Cry61 levels and clinical features in patients with rectal cancer.Results There were no significant differences in gender and age between the 2 groups(P>0.05),but there were significant differences in lymph node metastasis,tumor stage and differentiation between the two groups(P<0.05).The levels of COL10A1,COLⅣand Cry61 in poor group were significantly higher than those in good group(P<0.05).The levels of COL10A1,COLⅣand Cry61 were not related to the gender and age of patients,but were related to lymph node metastasis,stageⅢ~Ⅳand low differentiation.The levels of COL10A1,COLⅣand Cry61 in patients with lymph node metastasis,stageⅢ~Ⅳand low differentiation were significantly higher than those in patients without lymph node metastasis,stageⅠ~Ⅱand middle and high differentiation.The difference was significant(P<0.05).The combined detection of COL10A1,COLⅣand Cry61 had good predictive value for the prognosis of rectal cancer,with AUC of 0.863,sensitivity and specificity of 0.917 and 0.760,respectively.The combined detection of COL10A1,COLⅣand CRY61 had better predictive efficacy than that of a single indicator.The predicted thresholds were 6.840 ng/ml,158.965 ng/ml and 481.795 ng/l,respectively.Conclusion The expression levels of COL10A1,COLⅣand Cry61 are significantly increased in serum of patients with poor prognosis of rectal cancer.The combination of COL10A1,COLⅣand Cry61 has a good value in

关 键 词：直肠癌 COL10A1 COLⅣ Cry61 预后 

分 类 号：R735.37[医药卫生—肿瘤]