血清HIF-1α、CEA联合幽门螺杆菌检测对老年早期胃癌筛查的价值  

Value of Serum HIF-1αand CEA Combined with Helicobacter Pylori in Screening Early Gastric Cancer in Elderly Patients

作　　者：葛秀珍 张海云 庄培丽 GE Xiuzhen;ZHANG Haiyun;ZHUANG Peili(The First Affiliated Hospital of Xinxiang Medical College,Xinxiang,453100)

机构地区：[1]新乡医学院第一附属医院,453100

出　　处：《实用癌症杂志》2024年第8期1334-1337,共4页The Practical Journal of Cancer

摘　　要：目的探讨血清HIF-1α、CEA联合幽门螺杆菌(Hp)检测在老年早期胃癌筛查中的价值。方法收集因胃部不适行胃镜检查的患者107例,均行病理检查,采用双抗体夹心酶联免疫吸附法检测血清HIF-1α、CEA水平,采用13 C尿素呼气实验进行Hp定性检测。结果107例患者经病理检查发现,早期胃癌10例(胃癌组),癌前病变30例(癌前病变组),慢性浅表性胃炎67例(浅表性胃炎组)。再将癌前病变组、浅表性胃炎组67例均纳入对照组。三组患者血清HIF-1α、CEA、Hp阳性率比较,P<0.05。胃癌组与对照组性别、年龄、合并症、吸烟史、饮酒史、肌酐比较,P>0.05;两组HIF-1α、CEA、Hp阳性率比较,P<0.05。HIF-1α(OR:3.543,95%CI:2.054~11.652)、CEA(OR:3.239,95%CI:1.745~65.322)、Hp阳性率(OR:3.127,95%CI:1.341~6.875)均为老年早期胃癌发生的危险因素,血清HIF-1α、CEA联合Hp检测对老年早期胃癌的诊断效能均较单一检测效能更高(P<0.05)。结论血清HIF-1α、CEA联合幽门螺杆菌检测对老年早期胃癌筛查具有较高的诊断效能,可作为危险因素的评估指标。该联合检测方法的应用有助于提高早期胃癌的检出率,为老年胃癌筛查和早期诊断提供了有价值的参考依据。Objective To investigate the value of serum HIF-1αand CEA combined with Helicobacter pylori(Hp)in screening for early gastric cancer in elderly patients.Methods 107 patients who underwent gastroscopy due to stomach discomfort were collected and pathological examination was performed.Serum HIF-1αand CEA levels were detected by double antibody sandwich ELISA,and Hp was qualitatively detected by 13 C urea breath test.Results Pathological examination of 107 patients showed that there were 10 cases of early gastric cancer(gastric cancer group),30 cases of precancerous lesions(precancerous lesion group),and 67 cases of chronic superficial gastritis(superficial gastritis group).Then 67 cases of precancerous lesion group and superficial gastritis group were included in the control group.The positive rates of HIF-1α,CEA and Hp in serum were compared between the 3 groups,P<0.05.The positive rates of HIF-1α,CEA and Hp were compared between the 2 groups,P>0.05;the positive rates of HIF-1α,CEA and HP were compared between the 2 groups,P<0.05.HIF-1α(OR:3.543,95%CI:2.054~11.652),CEA(OR:3.239,95%CI:1.745~65.322),Hp positive rate(OR:3.127,95%CI:1.341-6.875)were risk factors for early gastric cancer in elderly patients.The diagnostic efficacy of serum HIF-1αand CEA combined with Hp was higher than that of single detection(P<0.05).Conclusion Serum HIF-1αand CEA combined with Helicobacter pylori detection have high diagnostic efficacy in elderly patients with early gastric cancer screening,and can be used as an evaluation index of risk factors.The application of the combined detection method is helpful to improve the detection rate of early gastric cancer,and provides a valuable reference for screening and early diagnosis of gastric cancer in the elderly.

关 键 词：老年人 早期胃癌 HIF-1Α CEA HP 筛查 

分 类 号：R735.2[医药卫生—肿瘤]