氨基酮戊酸光动力联合液氮冷冻疗法对非黑色素瘤性皮肤癌患者的疗效  

Effect of Aminoketone Valeric Acid Photodynamic Therapy Combined with Liquid Nitrogen Cryotherapy on Serological Parameters in Patients with Non Melanoma Skin Cancer

作　　者：邵雅坤 唐二云[1] 朱克彬 SHAO Yakun;TANG Eryun;ZHU Kebin(The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou,450000)

机构地区：[1]河南中医药大学第一附属医院,450000

出　　处：《实用癌症杂志》2024年第8期1381-1383,共3页The Practical Journal of Cancer

摘　　要：目的探讨氨基酮戊酸光动力(ALA-PDT)联合液氮冷冻疗法治疗非黑色素瘤性皮肤癌(NMSC)的临床效果及安全性。方法选取78例NMSC患者,按随机数字表法分为两组,各39例。对照组予以ALA-PDT治疗,观察组加用液氮冷冻治疗,持续治疗3个月。比较两组临床疗效、血清学指标及安全性。结果观察组总有效率较对照组高,治疗后IL-1β、TGF-β1水平低于对照组,有统计学差异(P<0.05);两组安全性相比,无统计学差异(P>0.05)。结论ALA-PDT联合液氮冷冻疗法可提高NMSC治疗效果,降低IL-1β、TGF-β1水平,安全可靠。Objective To investigate the clinical efficacy and safety of aminoketone valeric acid photodynamic therapy(ALA-PDT)combined with liquid nitrogen cryotherapy in the treatment of non melanoma skin cancer(NMSC).Methods 78 NMSC patients were selected and randomly divided into 2 groups,with 39 patients in each group.The control group received ALA-PDT treatment,while the observation group received liquid nitrogen cryotherapy for 3 months.Compare the clinical efficacy,serological indicators,and safety between two groups.Results The total effective rate of the observation group was higher than that of the control group,and IL-1 was observed after treatmentβ、TGF-βThe level of 1 was lower than that of the control group,with statistical differences(P<0.05);There was no statistically significant difference in safety between the 2 groups(P>0.05).Conclusion ALA-PDT combined with liquid nitrogen cryotherapy can improve the therapeutic effect of NMSC and reduce IL-1β、TGF-β1 level,is safe and reliable.

关 键 词：非黑色素瘤性皮肤癌 氨基酮戊酸光动力 液氮冷冻疗法 

分 类 号：R739.5[医药卫生—肿瘤]