WT1、NLR及LMR对儿童急性髓系白血病的诊断价值分析  

Analysis of the Diagnostic Value of WT1,NLR and LMR in Children Acute Myeloid Leukemia

作　　者：史利欢 陈静 谢昕 范朋凯 刘炜 SHI Lihuan;CHEN Jing;XIE Xin(Henan Provincial Children's Hospital,Zhengzhou,450018)

机构地区：[1]河南省儿童医院,450018

出　　处：《实用癌症杂志》2024年第8期1384-1386,共3页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20210627);河南省科技攻关项目(编号:232102310048)。

摘　　要：目的探讨WT1、NLR及LMR对儿童急性髓系白血病的诊断价值。方法选取73例AML初诊患儿作为研究组,另外选取同时期门诊体检的健康儿童作为对照组(50例),比较2组的WT1、NLR及LMR水平等差异。结果研究组患儿的NLR水平高于对照组,而LMR则较对照组低(P<0.05);随着危险度增高,AML患儿的NLR及WT1表达水平逐渐升高,而LMR水平逐渐降低(P<0.05);NLR、LMR及WT1检测鉴别为儿童AML分别为55例、59例及56例,联合检测鉴别儿童AML为69例;各指标联合检测对儿童AML鉴别诊断敏感度、特异度及AUC均明显高于NLR、LMR及WT1单独检测(P<0.05)。结论联合检测WT1及NLR、LMR可显著提高儿童AML的诊断率,但仍需进一步加大样本量行深入验证。Objective To investigate the diagnostic value of WT1,NLR and LMR in children acute myeloid leukemia.Methods 73 newly diagnosed children with AML were selected as the study group,and another healthy children with outpatient physical examination in the same time period were selected as the control group(50 cases)to compare the differences in WT1,NLR and LMR levels between the 2 groups.Results The level of NLR in the study group was higher than that in the control group,while LMR was lower than that in the control group(P<0.05);as the risk increased,the level of NLR and WT1 expression in children with AML gradually increased,while the level of LMR gradually decreased(P<0.05).NLR,LMR and WT1 tests identified 55,59 and 56 cases of AML in children,respectively,and the combined test identified 69 cases of AML in children;the sensitivity,specificity and AUC of the combined test of each index for the differential diagnosis of AML in children were significantly higher than that of the NLR,LMR and WT1 tests alone(P<0.05).Conclusion Combined detection of WT1 and NLR and LMR can significantly improve the diagnostic rate of AML in children,but further in-depth validation with larger sample size is needed.

关 键 词：中性粒细胞计数/淋巴细胞计数 淋巴细胞计数/单核细胞计数 肾母细胞瘤基因1 儿童急性髓系白血病 诊断价值 

分 类 号：R733.71[医药卫生—肿瘤]