胆汁酸在酒精性肝病中的作用研究进展  

Research progress on the role of bile acids in alcoholic liver disease

作　　者：李楠 赵雪 阿娜丽 梁贺然 戈娜[2] LI Nan;ZHAO Xue;A′nali;LIANG Heran;GE Na(School of Public Health,Baotou Medical College,Baotou 014040,China;不详)

机构地区：[1]包头医学院公共卫生学院,内蒙古包头014040 [2]包头医学院营养与食品健康研究所,内蒙古包头014040

出　　处：《实用医学杂志》2024年第15期2187-2193,共7页The Journal of Practical Medicine

基　　金：国家自然科学基金委员会地区项目(编号:82160618);内蒙古自然科学基金项目(编号:2023MS08041);内蒙古自治区卫生健康科技计划项目(编号:202201373);包头医学院创新团队发展计划(编号:bycxtd-11);包头医学院2023年硕士研究生科研创新资助项目(编号:bycx2023004,bycx2023007)。

摘　　要：酒精性肝病(alcoholic liver disease,ALD)是因大量和(或)长期饮酒所致的肝脏疾病。胆汁酸在肝脏中合成,通过肠肝循环调节机体,目前已有许多研究表明胆汁酸和酒精性肝病有密切联系,酒精摄入可通过影响胆汁酸合成及肠肝循环、肠道菌群等进而使肝脏损伤。本文总结了胆汁酸在酒精性肝病中的作用机制以及基于胆汁酸调节改善酒精性肝病的研究现状,以期为今后酒精性肝病的防治研究提供新思路。Alcoholic liver disease is liver disease caused by heavy and/or chronic alcohol consumption.Bile acids are synthesized in the liver and regulate the body through liver-intestinal circulation.Many studies have shown that bile acid is closely related to alcoholic liver disease.Alcohol intake can cause liver damage by affecting bile acid synthesis,hepato-enteric circulation and intestinal flora.This article summarizes the mechanism of action of bile acids in alcoholic liver disease and the current research status of improving alcoholic liver disease based on bile acid regulation,in order to provide new ideas for future research on the prevention and treatment of alcoholic liver disease.

关 键 词：酒精性肝病 胆汁酸 肠道菌群 肠肝循环 

分 类 号：R575[医药卫生—消化系统]